Cap-binding protein that recruits the ribosome to an mRNA. Held hostage by 4E-BP1 until mTORC1 phosphorylates the latter - the rate-limiting step of cap-dependent translation.
The clamp that starts reading mRNA.
Rate-limiting for cap-dependent initiation; a proto-oncogene in its own right when overexpressed.
| Tier | What it means | Studies |
|---|---|---|
| D | Mechanistic / in vitro / review | 4 |
No direct human evidence in the Atlas for this entity yet — everything below rests on animal or mechanistic work.
| Study | Year | Tier | Finding |
|---|---|---|---|
| THO2012 | 2012 | D | Used ribosome profiling with the complete inhibitor Torin1 to address a long-standing debate: in these cells, mTORC1's translational control runs largely through the 4E-BP family acting on a specific |
| HSI2012 | 2012 | D | Showed WHY mTOR-driven translation matters for cancer: in prostate cancer, oncogenic mTOR selectively translates a specific set of pro-invasion mRNAs that drive metastasis. An ATP-competitive mTOR inh |
| MAX2009 | 2009 | D | Review of the molecular mechanisms of mTOR-mediated translational control. |
| SCH2003 | 2003 | D | The TOS motif mediates raptor binding and controls multisite 4E-BP1 phosphorylation by mTORC1. |