TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

The mammalian target of rapamycin, mTOR, is a serine/threonine kinase that controls cell growth and proliferation via the translation regulators eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1). We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. However, it is unclear how the TOS motif in S6K1 and 4E-BP1 mediates mTOR signaling.

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Schalm, S. S., et al. (2003). TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Current biology : CB. https://doi.org/10.1016/s0960-9822(03)00329-4

@article{SCH2003,
  author       = {Schalm, S. S. and Blenis, J. and others},
  title        = {{TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function}},
  journal      = {Current biology : CB},
  year         = {2003},
  doi          = {10.1016/s0960-9822(03)00329-4},
  note         = {PMID: 12747827},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SCH2003) [Data set]. https://mtor-atlas.org/study/SCH2003/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SCH2003,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SCH2003},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SCH2003/},
  doi          = {10.5281/zenodo.22059963}
}