TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

Schalm SS, Fingar DC, Sabatini DM, Blenis J · 2003 · Current biology : CB · Atlas ID SCH2003

What this study shows

The TOS motif mediates raptor binding and controls multisite 4E-BP1 phosphorylation by mTORC1.

Abstract

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The mammalian target of rapamycin, mTOR, is a serine/threonine kinase that controls cell growth and proliferation via the translation regulators eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1). We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. However, it is unclear how the TOS motif in S6K1 and 4E-BP1 mediates mTOR signaling.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: In vitro) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	In vitro
Journal	Current biology : CB
Year	2003
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/s0960-9822(03)00329-4 · PMID 12747827

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical (TOS motif)
Target	mTOR / raptor / 4E-BP1
Model	In vitro
Effect	TOS-motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

In the Atlas

Links in the pathway map

Supports 4E-BP1 inhibits eIF4E

Cite this paper

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Schalm, S. S., Fingar, D. C., Sabatini, D. M., & Blenis, J. (2003). TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Current biology : CB. https://doi.org/10.1016/s0960-9822(03)00329-4

@article{SCH2003,
  author       = {Schalm, S. S. and Fingar, D. C. and Sabatini, D. M. and Blenis, J.},
  title        = {{TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function}},
  journal      = {Current biology : CB},
  year         = {2003},
  doi          = {10.1016/s0960-9822(03)00329-4},
  note         = {PMID: 12747827},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SCH2003) [Data set]. https://mtor-atlas.org/study/SCH2003/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SCH2003,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SCH2003},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SCH2003/},
  doi          = {10.5281/zenodo.22059963}
}

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