Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

The immunosuppressant rapamycin interferes with G1-phase progression in lymphoid and other cell types by inhibiting the function of the mammalian target of rapamycin (mTOR). mTOR was determined to be a terminal kinase in a signaling pathway that couples mitogenic stimulation to the phosphorylation of the eukaryotic initiation factor (eIF)-4E-binding protein, PHAS-I. The rapamycin-sensitive protein kinase activity of mTOR was required for phosphorylation of PHAS-I in insulin-stimulated human embryonic kidney cells.

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Brunn, G. J., et al. (1997). Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science. https://doi.org/10.1126/science.277.5322.99

@article{BRU1997,
  author       = {Brunn, G. J. and Abraham, R. T. and others},
  title        = {{Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin}},
  journal      = {Science},
  year         = {1997},
  doi          = {10.1126/science.277.5322.99},
  note         = {PMID: 9204908},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BRU1997) [Data set]. https://mtor-atlas.org/study/BRU1997/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BRU1997,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BRU1997},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BRU1997/},
  doi          = {10.5281/zenodo.22059963}
}