Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

The coordinated action of cell cycle progression and cell growth (an increase in cell size and cell mass) is critical for sustained cellular proliferation, yet the biochemical signals that control cell growth are poorly defined, particularly in mammalian systems. We find that cell growth and cell cycle progression are separable processes in mammalian cells and that growth to appropriate cell size requires mTOR- and PI3K-dependent signals.

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Fingar, D. C., et al. (2002). Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes & development. https://doi.org/10.1101/gad.995802

@article{FIN2002,
  author       = {Fingar, D. C. and Blenis, J. and others},
  title        = {{Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E}},
  journal      = {Genes & development},
  year         = {2002},
  doi          = {10.1101/gad.995802},
  note         = {PMID: 12080086},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record FIN2002) [Data set]. https://mtor-atlas.org/study/FIN2002/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_FIN2002,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record FIN2002},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/FIN2002/},
  doi          = {10.5281/zenodo.22059963}
}