Oliver's mTOR Atlas Evidence Platform
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Crosstalk dynamics between the circadian clock and the mTORC1 pathway

Guerrero-Morín JG, Santillán M · 2020 · Journal of Theoretical Biology · Atlas ID GUE2020

What this study shows

A mathematical model of how mTORC1 could tune the circadian clock. It suggests mTORC1 raises clock amplitude by controlling BMAL1 translation and shortens the period by controlling where BMAL1 sits in the cell, and that both levels are needed for robust oscillation. A model, not a measurement - it proposes mechanisms for RAM2018's observations rather than testing them.

Abstract

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Crosstalk between the circadian clock clockwork and cellular metabolic regulatory networks is crucial to ensure an adequate response of an organism to the day/night cycle. mTOR (mammalian/mechanistic target of rapamycin) is a master growth regulator and sensor of nutrient status, which is part of the mTOR complex 1 (mTORC1). While the circadian clock confers rhythmicity to the mTOR protein by regulating its degradation rate, mTORC1 activity diminishes period and augments amplitude of circadian oscillations at the cellular level by a currently unknown mechanism.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Deterministic differential-algebraic equation model (in silico only)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemDeterministic differential-algebraic equation model (in silico only)
JournalJournal of Theoretical Biology
Year2020
Peer reviewedYes
Record last updated2026-09-23
SourceDOI 10.1016/j.jtbi.2020.110360 · PMID 32522472

Extracted findings

InterventionNone (simulation)
TargetmTORC1; BMAL1 translation and localisation
ModelIn silico
EffectModel predicts translational control sets amplitude and localisation control sets period

In the Atlas

Related topics

mTORC1

Cite this paper

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Guerrero-Morín, J. G., & Santillán, M. (2020). Crosstalk dynamics between the circadian clock and the mTORC1 pathway. Journal of Theoretical Biology. https://doi.org/10.1016/j.jtbi.2020.110360

@article{GUE2020,
  author       = {Guerrero-Morín, J. G. and Santillán, M.},
  title        = {{Crosstalk dynamics between the circadian clock and the mTORC1 pathway}},
  journal      = {Journal of Theoretical Biology},
  year         = {2020},
  doi          = {10.1016/j.jtbi.2020.110360},
  note         = {PMID: 32522472},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record GUE2020) [Data set]. https://mtor-atlas.org/study/GUE2020/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GUE2020,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GUE2020},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GUE2020/},
  doi          = {10.5281/zenodo.22059963}
}