Crosstalk dynamics between the circadian clock and the mTORC1 pathway
What this study shows
A mathematical model of how mTORC1 could tune the circadian clock. It suggests mTORC1 raises clock amplitude by controlling BMAL1 translation and shortens the period by controlling where BMAL1 sits in the cell, and that both levels are needed for robust oscillation. A model, not a measurement - it proposes mechanisms for RAM2018's observations rather than testing them.
Abstract
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Crosstalk between the circadian clock clockwork and cellular metabolic regulatory networks is crucial to ensure an adequate response of an organism to the day/night cycle. mTOR (mammalian/mechanistic target of rapamycin) is a master growth regulator and sensor of nutrient status, which is part of the mTOR complex 1 (mTORC1). While the circadian clock confers rhythmicity to the mTOR protein by regulating its degradation rate, mTORC1 activity diminishes period and augments amplitude of circadian oscillations at the cellular level by a currently unknown mechanism.
Read the full abstract on PubMed →At a glance
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| Evidence type | M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Deterministic differential-algebraic equation model (in silico only)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is. |
| Study type | 5 - Mechanistic / In Vitro |
| Model system | Deterministic differential-algebraic equation model (in silico only) |
| Journal | Journal of Theoretical Biology |
| Year | 2020 |
| Peer reviewed | Yes |
| Record last updated | 2026-10-01 |
| Source | DOI 10.1016/j.jtbi.2020.110360 · PMID 32522472 |
Where this study fits
How this study connects to the pathway map, open questions, people and other studies in the Atlas.
People in the Atlas
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Researcher at the Monterrey unit of Cinvestav in Mexico and first author of a 2020 mathematical model of how mTORC1 could tune the body's daily clock
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Builds mathematical models of biological regulation, including how the circadian clock and mTORC1 influence each other
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Topics
Extracted findings
These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.
| Intervention | None (simulation) |
| Target | mTORC1; BMAL1 translation and localisation |
| Model | In silico |
| Effect | Model predicts translational control sets amplitude and localisation control sets period |
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