José G Guerrero-Morín

Researcher at the Monterrey unit of Cinvestav in Mexico and first author of a 2020 mathematical model of how mTORC1 could tune the body's daily clock

Unidad Monterrey, Centro de Investigación y de Estudios Avanzados del IPN (Cinvestav), Apodaca, Nuevo León (at the time of the study, 2020)

Almost every cell in the body runs a circadian clock, a loop of genes and proteins that rises and falls over about 24 hours. One of the central clock proteins is BMAL1. mTORC1, the growth-control complex, is one of the signals thought to affect the clock through BMAL1. José Guerrero-Morín was first author of a 2020 paper in the Journal of Theoretical Biology (GUE2020) that turned these observations into a mathematical model.

The model suggests that mTORC1 makes the clock's swings bigger by boosting the making (translation) of BMAL1, and changes the length of each cycle by controlling where BMAL1 sits inside the cell. Both effects together were needed for a strong, regular rhythm in the model. This is a computer model, not an experiment: it makes predictions that still have to be tested in cells or animals. It matters for the Atlas because it gives a testable picture of how growth signalling and daily timing might be linked.

The paper was written at the Monterrey unit of Cinvestav, a national research centre in Mexico, with Santillán as senior author. PubMed lists no other papers under this name, so later career steps could not be traced.

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