Moisés Santillán
Builds mathematical models of biological regulation, including how the circadian clock and mTORC1 influence each other
Researcher, Cinvestav Unidad Monterrey
Portrait: Frontiers Loop
Moisés Santillán is a researcher at the Monterrey unit of Cinvestav, Mexico's Center for Research and Advanced Studies of the National Polytechnic Institute. He builds mathematical models of how biological regulatory systems behave over time.
In the Atlas he is senior author of GUE2020, a computer model of crosstalk between the circadian clock and mTORC1. The model suggests that mTORC1 makes the clock's daily rhythm stronger by controlling how much BMAL1 protein is made, and shortens the cycle by controlling where BMAL1 sits in the cell. It is a model only and needs testing in cells or animals.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2020 | M | Crosstalk dynamics between the circadian clock and the mTORC1 pathway GUE2020 Senior author: mathematical model in which mTORC1 tunes circadian amplitude and period through BMAL1 (in silico only). |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Moisés Santillán.
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- José G Guerrero-Morín Researcher at the Monterrey unit of Cinvestav in Mexico and first author of a 2020 mathematical model of how mTORC1 could tune the body's daily clock
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