Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

The macrolide rapamycin blocks cell cycle progression in yeast and various animal cells by an unknown mechanism. We demonstrate that rapamycin blocks the phosphorylation and activation of the 70 kd S6 protein kinases (pp70S6K) in a variety of animal cells. The structurally related drug FK506 had no effect on pp70S6K activation but at high concentrations reversed the rapamycin-induced block, confirming the requirement for the rapamycin and FK506 receptor, FKBP.

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Chung, J., et al. (1992). Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell. https://doi.org/10.1016/0092-8674(92)90643-q

@article{CHU1992,
  author       = {Chung, J. and Blenis, J. and others},
  title        = {{Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases}},
  journal      = {Cell},
  year         = {1992},
  doi          = {10.1016/0092-8674(92)90643-q},
  note         = {PMID: 1377606},
}

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The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record CHU1992) [Data set]. https://mtor-atlas.org/study/CHU1992/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_CHU1992,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record CHU1992},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/CHU1992/},
  doi          = {10.5281/zenodo.22059963}
}