Glutamine alleviates bisphenol A-induced jejunal injury in piglets involving mitochondrial function restoration and AMPK-mTOR signaling regulation.

Xie J, Liu Z, Liu W, Qin P, Liu M, Wang H, Di Y, Liu R, Yang W, Jiao N · 2026 · Ecotoxicology and Environmental Safety · Atlas ID XIE2026

What this study shows

Glutamine supplementation alleviated bisphenol A-induced jejunal injury in piglets, restoring mitochondrial energy metabolism and barrier integrity alongside modulation of AMPK-mTOR signalling.

Abstract

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Bisphenol A (BPA) disrupts intestinal homeostasis and promotes epithelial injury in piglets. Glutamine (Gln) is a vital energy substrate for intestinal epithelial cells. Piglet and porcine intestinal epithelial cell models were used. BPA exposure impaired intestinal morphology and barrier integrity, with reduced tight junction protein expression, decreased epithelial renewal capacity, altered JNK/MAPK signaling and disrupted mitochondrial structure and energy metabolism.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Piglet; porcine intestinal epithelial cells); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Piglet; porcine intestinal epithelial cells
Journal	Ecotoxicology and Environmental Safety
Year	2026
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.ecoenv.2026.120698 · PMID 42660031

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Dietary glutamine supplementation
Target	AMPK-mTOR; mitochondrial energy metabolism
Model	Pig
Effect	Improved tight junction expression, epithelial renewal and mitochondrial function under BPA stress

In the Atlas

Cite this paper

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Xie, J., Liu, Z., Liu, W., Qin, P., Liu, M., Wang, H., Di, Y., Liu, R., Yang, W., & Jiao, N. (2026). Glutamine alleviates bisphenol A-induced jejunal injury in piglets involving mitochondrial function restoration and AMPK-mTOR signaling regulation. Ecotoxicology and Environmental Safety. https://doi.org/10.1016/j.ecoenv.2026.120698

@article{XIE2026,
  author       = {Xie, J. and Liu, Z. and Liu, W. and Qin, P. and Liu, M. and Wang, H. and Di, Y. and Liu, R. and Yang, W. and Jiao, N.},
  title        = {{Glutamine alleviates bisphenol A-induced jejunal injury in piglets involving mitochondrial function restoration and AMPK-mTOR signaling regulation}},
  journal      = {Ecotoxicology and Environmental Safety},
  year         = {2026},
  doi          = {10.1016/j.ecoenv.2026.120698},
  note         = {PMID: 42660031},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record XIE2026) [Data set]. https://mtor-atlas.org/study/XIE2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_XIE2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record XIE2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/XIE2026/},
  doi          = {10.5281/zenodo.22059963}
}

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