Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, …, Harrison DE · 2012 · J Gerontol A Biol Sci Med Sci · Atlas ID STR2012

What this study shows

None of five popular longevity compounds had a statistically significant effect on lifespan. The paper explicitly states the ITP's mission is to publish all results, positive or negative - the exact registry model this Atlas should emulate.

Abstract

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The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal study reporting a negative or null result (model: Mouse (genetically heterogeneous, ITP, 3 sites)); a well-designed null result is still evidence, and the code names the system studied, not the importance.
Study type	4 - Animal Study
Model system	Mouse (genetically heterogeneous, ITP, 3 sites)
Journal	J Gerontol A Biol Sci Med Sci
Year	2012
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1093/gerona/gls070 · PMID 22451473 · Free full text (PMC3598361)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Resveratrol, green tea extract, curcumin, oxaloacetic acid, MCT oil (dietary)
Target	Nutrient/aging pathways (not mTOR-specific)
Model	Mouse (genetically heterogeneous, NIA ITP, 3 sites)
Effect	Lifespan test: these compounds did not robustly extend lifespan (largely negative ITP result)

In the Atlas

Cite this paper

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Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., de Cabo, R., Fernandez, E., Guo, W., Javors, M., Kirkland, J. L., Nelson, J. F., Sinclair, D. A., Teter, B., Williams, D., Zaveri, N., Nadon, N. L., & Harrison, D. E. (2012). Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. https://doi.org/10.1093/gerona/gls070

@article{STR2012,
  author       = {Strong, R. and Miller, R. A. and Astle, C. M. and Baur, J. A. and de Cabo, R. and Fernandez, E. and Guo, W. and Javors, M. and Kirkland, J. L. and Nelson, J. F. and Sinclair, D. A. and Teter, B. and Williams, D. and Zaveri, N. and Nadon, N. L. and Harrison, D. E.},
  title        = {{Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice}},
  journal      = {J Gerontol A Biol Sci Med Sci},
  year         = {2012},
  doi          = {10.1093/gerona/gls070},
  note         = {PMID: 22451473},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record STR2012) [Data set]. https://mtor-atlas.org/study/STR2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_STR2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record STR2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/STR2012/},
  doi          = {10.5281/zenodo.22059963}
}

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