None of five popular longevity compounds had a statistically significant effect on lifespan. The paper explicitly states the ITP's mission is to publish all results, positive or negative - the exact registry model this Atlas should emulate.
| Evidence tier | C Animal in vivo |
| Study type | 4 - Animal Study |
| Model system | Mouse (genetically heterogeneous, ITP, 3 sites) |
| Journal | J Gerontol A Biol Sci Med Sci |
| Year | 2012 |
| Peer reviewed | Yes |
| Source | DOI 10.1093/gerona/gls070 · PMID 22451473 · Free full text (PMC3598361) |
The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive. We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin, oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice. Each agent was administered beginning at 4 months of age. None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only.
| Intervention | Resveratrol, green tea extract, curcumin, oxaloacetic acid, MCT oil (dietary) |
| Target | Nutrient/aging pathways (not mTOR-specific) |
| Model | Mouse (genetically heterogeneous, NIA ITP, 3 sites) |
| Effect | Lifespan test: these compounds did not robustly extend lifespan (largely negative ITP result) |