Resveratrol

Drug · 3 studies in the Atlas

A plant compound found in red wine, popularized as an activator of 'sirtuin' longevity genes and a calorie-restriction mimic. It failed to extend lifespan in a rigorous mouse study and showed no metabolic benefit in a human clinical trial.

Plant polyphenol popularized as a sirtuin activator and 'calorie-restriction mimetic'; failed to extend lifespan in ITP mouse studies and showed no metabolic benefit in a human RCT.

TL;DR. Resveratrol appears in 3 curated studies in Oliver's mTOR Atlas: 1 in people (1 human study); 2 in animal models.

Which mTOR drugs are in development now, and why: mTOR drugs in development →

Evidence at a glance

Evidence	What it means	Studies
H	Human study	1
A	Animal model	2

Studies

Year	Evidence	Study
2013	H	High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition POU2013 4 weeks of high-dose resveratrol had no effect on insulin sensitivity, blood pressure, or body composition - directly contradicting the promising rodent data that drove the original hype.
2012	A	Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice STR2012 None of five popular longevity compounds had a statistically significant effect on lifespan. The paper explicitly states the ITP's mission is to publish all results, positive or negative - the exact registry model this Atlas should emulate.
2011	A	Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice MIL2011 In the same experimental design that showed rapamycin extended median lifespan by 10-18%, neither resveratrol nor simvastatin had any significant effect on survival - a direct head-to-head negative control run at the same time, in the same mice.

Related entities

Longevity 2CurcuminMCT oilRapamycin 1Oxaloacetic acidmTOR 1SimvastatinGreen tea extract

Cite this page

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Barton, O. (2026). Resveratrol [Entity page]. In Oliver's mTOR Atlas [Data set]. https://mtor-atlas.org/drug/resveratrol/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_drug_resveratrol,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}: Resveratrol},
  howpublished = {Entity page in a data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/drug/resveratrol/},
  doi          = {10.5281/zenodo.22059963}
}

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