Rheb binds and regulates the mTOR kinase

Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J · 2005 · Current biology : CB · Atlas ID LON2005

What this study shows

Rheb binds the mTOR kinase domain and directly stimulates its activity.

Abstract

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The target of rapamycin (TOR), in complex with the proteins raptor and LST8 (TOR complex 1), phosphorylates the p70S6K and 4E-BP1 to promote mRNA translation. Genetic evidence establishes that TOR complex activity in vivo requires the small GTPase Rheb, and overexpression of Rheb can rescue TOR from inactivation in vivo by amino-acid withdrawal. The Tuberous Sclerosis heterodimer (TSC1/TSC2) functions as a Rheb GTPase activator and inhibits TOR signaling in vivo.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: In vitro) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	In vitro
Journal	Current biology : CB
Year	2005
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cub.2005.02.053 · PMID 15854902

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical (Rheb)
Target	Rheb / mTORC1
Model	In vitro
Effect	Rheb binds and directly regulates the mTOR kinase (with TSC1/2 acting as its GAP)

In the Atlas

Cite this paper

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Long, X., Lin, Y., Ortiz-Vega, S., Yonezawa, K., & Avruch, J. (2005). Rheb binds and regulates the mTOR kinase. Current biology : CB. https://doi.org/10.1016/j.cub.2005.02.053

@article{LON2005,
  author       = {Long, X. and Lin, Y. and Ortiz-Vega, S. and Yonezawa, K. and Avruch, J.},
  title        = {{Rheb binds and regulates the mTOR kinase}},
  journal      = {Current biology : CB},
  year         = {2005},
  doi          = {10.1016/j.cub.2005.02.053},
  note         = {PMID: 15854902},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LON2005) [Data set]. https://mtor-atlas.org/study/LON2005/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LON2005,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LON2005},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LON2005/},
  doi          = {10.5281/zenodo.22059963}
}

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