Xiaomeng Long
Discovered that Rheb binds directly to the mTOR kinase domain and switches it on
Research staff, MGH/Harvard (Joseph Avruch lab, 2002–2009) · pre-2002 training and post-2009 career not publicly documented
Avruch Lab, Massachusetts General Hospital / Harvard Medical School ↗
By 2005 (LON2005), Long showed Rheb binds straight onto the mTOR kinase domain and that binding stimulates catalytic activity — a physical, mechanistic link between GTPase and kinase.
Long's traceable record sits entirely inside the Avruch lab, 2002–2009, ending with a 2009 review co-authorship. No public record before/after this window turned up — common for researchers from this era who moved into industry without a web footprint.
Milestones in the Atlas
| Year | Evidence | Study |
|---|---|---|
| 2002 | M | Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action HARA2002 Co-author on the founding Raptor paper (Avruch/Yonezawa collaboration). |
| 2005 | M | Rheb binds and regulates the mTOR kinase LON2005 Rheb binds directly to the mTOR kinase domain and stimulates its activity. |