Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, Benzer S · 2004 · Current Biology · Atlas ID KAP2004

What this study shows

Genetically reducing TOR pathway activity extends fruit fly lifespan, overlapping with dietary restriction effects.

Abstract

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In many species, reducing nutrient intake without causing malnutrition extends lifespan. Like DR (dietary restriction), modulation of genes in the insulin-signaling pathway, known to alter nutrient sensing, has been shown to extend lifespan in various species. In Drosophila, the target of rapamycin (TOR) and the insulin pathways have emerged as major regulators of growth and size. Hence we examined the role of TOR pathway genes in regulating lifespan by using Drosophila.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Drosophila melanogaster); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Drosophila melanogaster
Journal	Current Biology
Year	2004
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.cub.2004.03.059 · PMID 15186745 · Free full text (PMC2754830)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic (TOR pathway modulation)
Target	TOR
Model	Drosophila melanogaster
Effect	Reducing TOR pathway activity extends fly lifespan, overlapping with dietary restriction

In the Atlas

Cite this paper

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Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004). Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Current Biology. https://doi.org/10.1016/j.cub.2004.03.059

@article{KAP2004,
  author       = {Kapahi, P. and Zid, B. M. and Harper, T. and Koslover, D. and Sapin, V. and Benzer, S.},
  title        = {{Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway}},
  journal      = {Current Biology},
  year         = {2004},
  doi          = {10.1016/j.cub.2004.03.059},
  note         = {PMID: 15186745},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KAP2004) [Data set]. https://mtor-atlas.org/study/KAP2004/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KAP2004,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KAP2004},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KAP2004/},
  doi          = {10.5281/zenodo.22059963}
}

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