Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

In many species, reducing nutrient intake without causing malnutrition extends lifespan. Like DR (dietary restriction), modulation of genes in the insulin-signaling pathway, known to alter nutrient sensing, has been shown to extend lifespan in various species. In Drosophila, the target of rapamycin (TOR) and the insulin pathways have emerged as major regulators of growth and size. Hence we examined the role of TOR pathway genes in regulating lifespan by using Drosophila.

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Kapahi, P., et al. (2004). Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Current Biology. https://doi.org/10.1016/j.cub.2004.03.059

@article{KAP2004,
  author       = {Kapahi, P. and others},
  title        = {{Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway}},
  journal      = {Current Biology},
  year         = {2004},
  doi          = {10.1016/j.cub.2004.03.059},
  note         = {PMID: 15186745},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KAP2004) [Data set]. https://mtor-atlas.org/study/KAP2004/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KAP2004,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KAP2004},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KAP2004/},
  doi          = {10.5281/zenodo.22059963}
}