mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

Autophagy is important in the basal or stress-induced clearance of bulk cytosol, damaged organelles, pathogens and selected proteins by specific vesicles, the autophagosomes. Following mTOR (mammalian target of rapamycin) inhibition, autophagosome formation is primed by the ULK1 and the beclin-1-Vps34-AMBRA1 complexes, which are linked together by a scaffold platform, the exocyst. Although several regulative steps have been described along this pathway, few targets of mTOR are known, and the cross-talk between ULK1 and beclin 1 complexes is still not fully understood.

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Nazio, F., et al. (2013). mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6. Nature cell biology. https://doi.org/10.1038/ncb2708

@article{NAZ2013,
  author       = {Nazio, F. and Cecconi, F. and others},
  title        = {{mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6}},
  journal      = {Nature cell biology},
  year         = {2013},
  doi          = {10.1038/ncb2708},
  note         = {PMID: 23524951},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record NAZ2013) [Data set]. https://mtor-atlas.org/study/NAZ2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_NAZ2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record NAZ2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/NAZ2013/},
  doi          = {10.5281/zenodo.22059963}
}