Dwarf mice and the ageing process

Brown-Borg HM, Borg KE, Meliska CJ, Bartke A · 1996 · Nature · Atlas ID BRO1996

What this study shows

Mice with growth hormone deficiency lived substantially longer than normal littermates - founding observation linking reduced growth-signaling to mammalian longevity.

Abstract

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(Brief communication; no formal abstract in PubMed — editorial summary.) This landmark report shows that Ames dwarf mice, which carry a mutation causing combined deficiency of growth hormone, prolactin and thyroid-stimulating hormone, live substantially longer than their normal littermates (both sexes).

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Ames dwarf mice (growth-hormone deficient)); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Ames dwarf mice (growth-hormone deficient)
Journal	Nature
Year	1996
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/384033a0 · PMID 8900272

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic – Ames dwarf mutation (GH/prolactin/TSH deficiency)
Target	GH/IGF-1 axis (upstream of PI3K-Akt-mTOR)
Model	Mouse (Ames dwarf)
Effect	Substantially longer lifespan vs normal littermates (both sexes) – early evidence linking reduced growth signaling to longevity

In the Atlas

Cite this paper

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Brown-Borg, H. M., Borg, K. E., Meliska, C. J., & Bartke, A. (1996). Dwarf mice and the ageing process. Nature. https://doi.org/10.1038/384033a0

@article{BRO1996,
  author       = {Brown-Borg, H. M. and Borg, K. E. and Meliska, C. J. and Bartke, A.},
  title        = {{Dwarf mice and the ageing process}},
  journal      = {Nature},
  year         = {1996},
  doi          = {10.1038/384033a0},
  note         = {PMID: 8900272},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BRO1996) [Data set]. https://mtor-atlas.org/study/BRO1996/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BRO1996,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BRO1996},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BRO1996/},
  doi          = {10.5281/zenodo.22059963}
}

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