Oliver's mTOR Atlas Evidence Platform
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The 3.2-Å resolution structure of human mTORC2.

Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T · 2020 · Science advances · Atlas ID SCA2020

What this study shows

The 3.2 A cryo-EM structure of human mTORC2 pinpoints Rictor's C-terminus as the source of rapamycin insensitivity.

Abstract

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The protein kinase mammalian target of rapamycin (mTOR) is the central regulator of cell growth. Aberrant mTOR signaling is linked to cancer, diabetes, and neurological disorders. mTOR exerts its functions in two distinct multiprotein complexes, mTORC1 and mTORC2. Here, we report a 3.2-A resolution cryo-EM reconstruction of mTORC2.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cryo-EM structure) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemCryo-EM structure
JournalScience advances
Year2020
Peer reviewedYes
Record last updated2026-10-01
SourceDOI 10.1126/sciadv.abc1251 · PMID 33158864 · Free full text (PMC7673708)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

InterventionStructural (cryo-EM)
TargetmTORC2 (Rictor/SIN1)
ModelCryo-EM structure
Effect3.2-Å cryo-EM structure of human mTORC2 reveals the entangled Rictor and SIN1 folds

In the Atlas

Links in the pathway map

Cite this paper

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Scaiola, A., Mangia, F., Imseng, S., Boehringer, D., Berneiser, K., Shimobayashi, M., Stuttfeld, E., Hall, M. N., Ban, N., & Maier, T. (2020). The 3.2-Å resolution structure of human mTORC2. Science advances. https://doi.org/10.1126/sciadv.abc1251

@article{SCA2020,
  author       = {Scaiola, A. and Mangia, F. and Imseng, S. and Boehringer, D. and Berneiser, K. and Shimobayashi, M. and Stuttfeld, E. and Hall, M. N. and Ban, N. and Maier, T.},
  title        = {{The 3.2-Å resolution structure of human mTORC2}},
  journal      = {Science advances},
  year         = {2020},
  doi          = {10.1126/sciadv.abc1251},
  note         = {PMID: 33158864},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record SCA2020) [Data set]. https://mtor-atlas.org/study/SCA2020/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SCA2020,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SCA2020},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SCA2020/},
  doi          = {10.5281/zenodo.22059963}
}
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