The 3.2-A resolution structure of human mTORC2

Scaiola A, Maier T et al. · 2020 · Science advances · Atlas ID SCA2020

What this study shows

The 3.2 A cryo-EM structure of human mTORC2 pinpoints Rictor's C-terminus as the source of rapamycin insensitivity.

Abstract

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The protein kinase mammalian target of rapamycin (mTOR) is the central regulator of cell growth. Aberrant mTOR signaling is linked to cancer, diabetes, and neurological disorders. mTOR exerts its functions in two distinct multiprotein complexes, mTORC1 and mTORC2. Here, we report a 3.2-A resolution cryo-EM reconstruction of mTORC2.

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At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cryo-EM structure) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Cryo-EM structure
Journal	Science advances
Year	2020
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1126/sciadv.abc1251 · PMID 33158864 · Free full text (PMC7673708)

Extracted findings

Intervention	Structural (cryo-EM)
Target	mTORC2 (Rictor/SIN1)
Model	Cryo-EM structure
Effect	3.2-Å cryo-EM structure of human mTORC2 reveals the entangled Rictor and SIN1 folds

Cite this paper

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Scaiola, A., et al. (2020). The 3.2-A resolution structure of human mTORC2. Science advances. https://doi.org/10.1126/sciadv.abc1251

@article{SCA2020,
  author       = {Scaiola, A. and Maier, T. and others},
  title        = {{The 3.2-A resolution structure of human mTORC2}},
  journal      = {Science advances},
  year         = {2020},
  doi          = {10.1126/sciadv.abc1251},
  note         = {PMID: 33158864},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SCA2020) [Data set]. https://mtor-atlas.org/study/SCA2020/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SCA2020,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SCA2020},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SCA2020/},
  doi          = {10.5281/zenodo.22059963}
}