Regulation of mTORC1 by PI3K signaling

Dibble CC, Cantley LC · 2015 · Trends in cell biology · Atlas ID DIB2015

What this study shows

Review of mTORC1 regulation by PI3K signalling.

Abstract

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The class I phosphoinositide 3-kinase (PI3K)-mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) signaling network directs cellular metabolism and growth.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Trends in cell biology
Year	2015
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.tcb.2015.06.002 · PMID 26159692 · Free full text (PMC4734635)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	PI3K / mTORC1
Model	Review
Effect	Reviews how PI3K signaling activates mTORC1

In the Atlas

Cite this paper

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Dibble, C. C., & Cantley, L. C. (2015). Regulation of mTORC1 by PI3K signaling. Trends in cell biology. https://doi.org/10.1016/j.tcb.2015.06.002

@article{DIB2015,
  author       = {Dibble, C. C. and Cantley, L. C.},
  title        = {{Regulation of mTORC1 by PI3K signaling}},
  journal      = {Trends in cell biology},
  year         = {2015},
  doi          = {10.1016/j.tcb.2015.06.002},
  note         = {PMID: 26159692},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record DIB2015) [Data set]. https://mtor-atlas.org/study/DIB2015/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_DIB2015,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record DIB2015},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/DIB2015/},
  doi          = {10.5281/zenodo.22059963}
}

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