The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors.

Read the full abstract on PubMed →

Wolfson, R. L., et al. (2017). The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. Cell metabolism. https://doi.org/10.1016/j.cmet.2017.07.001

@article{WOLF2017,
  author       = {Wolfson, R. L. and Sabatini, D. M. and others},
  title        = {{The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway}},
  journal      = {Cell metabolism},
  year         = {2017},
  doi          = {10.1016/j.cmet.2017.07.001},
  note         = {PMID: 28768171},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WOLF2017) [Data set]. https://mtor-atlas.org/study/WOLF2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WOLF2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WOLF2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WOLF2017/},
  doi          = {10.5281/zenodo.22059963}
}