mTORC2 Promotes Tumorigenesis via Lipid Synthesis

Guri Y, Hall MN et al. · 2017 · Cancer cell · Atlas ID GUR2017

What this study shows

mTORC2 promotes tumorigenesis through control of de novo lipid synthesis.

Abstract

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Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying mechanisms are poorly understood. We describe an mTOR-driven mouse model that displays hepatosteatosis progressing to hepatocellular carcinoma (HCC). Longitudinal proteomic, lipidomics, and metabolomic analyses revealed that hepatic mTORC2 promotes de novo fatty acid and lipid synthesis, leading to steatosis and tumor development. In particular, mTORC2 stimulated sphingolipid (glucosylceramide) and glycerophospholipid (cardiolipin) synthesis.

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At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse; cells); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse; cells
Journal	Cancer cell
Year	2017
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1016/j.ccell.2017.11.011 · PMID 29232555

Extracted findings

Intervention	Genetic mTOR-driven mouse model
Target	mTORC2
Model	Mouse; cells
Effect	Hepatic mTORC2 promotes de novo fatty-acid/lipid synthesis (sphingolipids, glycerophospholipids) driving steatosis → hepatocellular carcinoma

In the Atlas

Cite this paper

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Guri, Y., et al. (2017). mTORC2 Promotes Tumorigenesis via Lipid Synthesis. Cancer cell. https://doi.org/10.1016/j.ccell.2017.11.011

@article{GUR2017,
  author       = {Guri, Y. and Hall, M. N. and others},
  title        = {{mTORC2 Promotes Tumorigenesis via Lipid Synthesis}},
  journal      = {Cancer cell},
  year         = {2017},
  doi          = {10.1016/j.ccell.2017.11.011},
  note         = {PMID: 29232555},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GUR2017) [Data set]. https://mtor-atlas.org/study/GUR2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GUR2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GUR2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GUR2017/},
  doi          = {10.5281/zenodo.22059963}
}