mTORC2 Promotes Tumorigenesis via Lipid Synthesis

Guri Y, Colombi M, Dazert E, Hindupur SK, Roszik J, Moes S, Jenoe P, Heim MH, Riezman I, Riezman H, Hall MN · 2017 · Cancer cell · Atlas ID GUR2017

What this study shows

mTORC2 promotes tumorigenesis through control of de novo lipid synthesis.

Abstract

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Dysregulated mammalian target of rapamycin (mTOR) promotes cancer, but underlying mechanisms are poorly understood. We describe an mTOR-driven mouse model that displays hepatosteatosis progressing to hepatocellular carcinoma (HCC). Longitudinal proteomic, lipidomics, and metabolomic analyses revealed that hepatic mTORC2 promotes de novo fatty acid and lipid synthesis, leading to steatosis and tumor development. In particular, mTORC2 stimulated sphingolipid (glucosylceramide) and glycerophospholipid (cardiolipin) synthesis.

Read the full abstract on PubMed →

At a glance

Evidence type	A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse; cells); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type	4 - Animal Study
Model system	Mouse; cells
Journal	Cancer cell
Year	2017
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1016/j.ccell.2017.11.011 · PMID 29232555

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic mTOR-driven mouse model
Target	mTORC2
Model	Mouse; cells
Effect	Hepatic mTORC2 promotes de novo fatty-acid/lipid synthesis (sphingolipids, glycerophospholipids) driving steatosis → hepatocellular carcinoma

In the Atlas

Links in the pathway map

Supports mTORC2 activates Lipid synthesis

Cite this paper

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Guri, Y., Colombi, M., Dazert, E., Hindupur, S. K., Roszik, J., Moes, S., Jenoe, P., Heim, M. H., Riezman, I., Riezman, H., & Hall, M. N. (2017). mTORC2 Promotes Tumorigenesis via Lipid Synthesis. Cancer cell. https://doi.org/10.1016/j.ccell.2017.11.011

@article{GUR2017,
  author       = {Guri, Y. and Colombi, M. and Dazert, E. and Hindupur, S. K. and Roszik, J. and Moes, S. and Jenoe, P. and Heim, M. H. and Riezman, I. and Riezman, H. and Hall, M. N.},
  title        = {{mTORC2 Promotes Tumorigenesis via Lipid Synthesis}},
  journal      = {Cancer cell},
  year         = {2017},
  doi          = {10.1016/j.ccell.2017.11.011},
  note         = {PMID: 29232555},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record GUR2017) [Data set]. https://mtor-atlas.org/study/GUR2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_GUR2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record GUR2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/GUR2017/},
  doi          = {10.5281/zenodo.22059963}
}

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