Yakir Guri
Showed mTORC2 drives liver cancer by rewiring lipid and sphingolipid synthesis
Botnar Research Centre for Child Health (BRCCH; affiliation on 2023 publications, renamed Basel Research Centre for Child Health in 2024) · University Hospital Basel (Internal Medicine) · MD-PhD, Biozentrum, Univ. of Basel (Hall lab)
Hall Lab, Biozentrum, University of Basel (Basel, Switzerland) ↗ Lab lineagetrained under Michael N. Hall → ORCID0000-0003-4273-4603 ↗
Portrait: Botnar Research Centre for Child Health (BRCCH)
In a fatty-liver-to-HCC mouse model, showed mTORC2 drives tumor formation by ramping up de novo lipid/sphingolipid synthesis (GUR2017); blocking synthesis prevented tumors. Co-authored a review (GUR2016) on mTOR as a resistance mechanism against targeted cancer drugs.
MD-PhD; returned to clinical medicine at University Hospital Basel (treated COVID-19 patients), now also affiliated with BRCCH.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2016 | R | mTOR Signaling Confers Resistance to Targeted Cancer Drugs GUR2016 Review of mTOR signaling conferring resistance to targeted cancer drugs. |
| 2017 | A | mTORC2 Promotes Tumorigenesis via Lipid Synthesis GUR2017 mTORC2 promotes tumorigenesis via de novo lipid synthesis. |
Co-authors in the Atlas 4
People with a profile here who share at least one study with Yakir Guri.
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- Michael N. Hall 2 shared studies Discovered TOR in yeast in 1991 and established it as a central controller of cell growth that responds to nutrients. His lab later showed that TOR works in two distinct complexes, TORC1 and TORC2, only one of which is blocked by rapamycin
- Markus H. Heim Basel hepatologist who studies how the liver responds to viral infection and how liver cancer develops, and a co-author of the study linking mTORC2 to fat synthesis in liver tumours
- Paul Jenoe Protein chemist who ran mass spectrometry and protein sequencing at the Biozentrum Basel for decades and contributed protein analysis to many mTOR studies from Michael Hall's lab
- Suzette Moes Protein scientist at the Biozentrum Basel's proteomics facility who, with Paul Jenö, carried out mass spectrometry for many mTOR studies from Michael Hall's lab
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