mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM · 2010 · Nature · Atlas ID SEN2010

What this study shows

mTORC1 controls fasting-induced hepatic ketogenesis via PPARalpha, and this is blunted with age.

Abstract

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The multi-component mechanistic target of rapamycin complex 1 (mTORC1) kinase is the central node of a mammalian pathway that coordinates cell growth with the availability of nutrients, energy and growth factors. Progress has been made in the identification of mTORC1 pathway components and in understanding their functions in cells, but there is relatively little known about the role of the pathway in vivo. Specifically, we have little knowledge regarding the role mTORC1 has in liver physiology.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mouse/cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mouse/cells
Journal	Nature
Year	2010
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/nature09584 · PMID 21179166

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic (raptor liver knockout)
Target	mTORC1 / PPARα / ketogenesis
Model	Mouse/cells
Effect	mTORC1 controls fasting-induced ketogenesis (via PPARα); this control is blunted with ageing

In the Atlas

Links in the pathway map

Supports Raptor required-for mTORC1
Supports TSC1/TSC2 inhibits mTORC1

Cite this paper

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Sengupta, S., Peterson, T. R., Laplante, M., Oh, S., & Sabatini, D. M. (2010). mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature. https://doi.org/10.1038/nature09584

@article{SEN2010,
  author       = {Sengupta, S. and Peterson, T. R. and Laplante, M. and Oh, S. and Sabatini, D. M.},
  title        = {{mTORC1 controls fasting-induced ketogenesis and its modulation by ageing}},
  journal      = {Nature},
  year         = {2010},
  doi          = {10.1038/nature09584},
  note         = {PMID: 21179166},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SEN2010) [Data set]. https://mtor-atlas.org/study/SEN2010/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SEN2010,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SEN2010},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SEN2010/},
  doi          = {10.5281/zenodo.22059963}
}

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