Timothy R. Peterson
Discovered DEPTOR, an inhibitor that binds mTOR in both complexes and is overexpressed in some multiple myelomas. He also showed that mTORC1 controls fat synthesis by regulating where the enzyme lipin 1 sits in the cell, and through it the SREBP pathway
CEO, BIOIO · previously ran a lab at Washington University School of Medicine in St. Louis · PhD, David Sabatini lab, Whitehead Institute/MIT
Profile, WashU Musculoskeletal Center (St. Louis, Missouri, USA) ↗ Lab lineagetrained under David M. Sabatini →
Portrait: Washington University Musculoskeletal Research Center
Tim Peterson did his graduate work in David Sabatini's lab, where in 2009 he led the discovery of DEPTOR, a protein that binds mTOR directly and inhibits both mTORC1 and mTORC2 — and that is selectively overexpressed in a subset of multiple myeloma cells, which depend on it for survival despite it being an mTOR inhibitor, a paradox his paper worked out mechanistically.
He went on to show that mTORC1 also controls lipin 1 localization to regulate the SREBP lipid-synthesis pathway, identifying a mechanism by which mTORC1 promotes SREBP function. He went on to run his own lab at Washington University in St. Louis, studying genomics, metabolism and aging, and now leads the company BIOIO.
The timeline below follows Peterson's contributions gathered in this Atlas.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2007 | M | PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase SAN2007 Co-authors the discovery of PRAS40 as an insulin-regulated inhibitor of the mTORC1 protein kinase. |
| 2008 | M | The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 SAN2008 Identifies the Rag GTPase family as the missing link that lets mTORC1 sense amino acids by controlling whether mTOR is positioned near its activator Rheb. |
| 2009 | M | DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival PET2009 Leads the discovery of DEPTOR, an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. |
| 2010 | M | mTORC1 controls fasting-induced ketogenesis and its modulation by ageing SEN2010 mTORC1 controls fasting-induced hepatic ketogenesis via PPARalpha, and this is blunted with age. |
| 2011 | M | The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling HSU2011 mTOR-dependent phosphoproteomics reveal Grb10 as a substrate mediating feedback inhibition of PI3K. |
| 2011 | M | mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway PET2011 Shows mTOR complex 1 regulates lipin 1 localization to control the SREBP lipid-synthesis pathway. |
Co-authors in the Atlas 14
People with a profile here who share at least one study with Timothy R. Peterson.
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- David M. Sabatini 6 shared studies Identified mTOR (as RAFT1) in 1994. His lab then mapped much of the machinery around it: raptor and rictor at the core of mTORC1 and mTORC2, the Rag–Ragulator system that docks mTORC1 on the lysosome, and the sensors that detect leucine, arginine and SAM
- Seong A. Kang 4 shared studies Contributed to the Sabatini-lab studies that identified PRAS40 and DEPTOR, two of the cell's own mTOR inhibitors, and to the first characterisation of the mTOR inhibitor Torin1
- Carson C. Thoreen 3 shared studies Used Torin1, one of the first ATP-competitive mTOR inhibitors, to reveal functions of mTORC1 that rapamycin cannot block. He then showed that mTORC1 controls translation of mRNAs for the protein-making machinery mainly through the 4E-BP proteins
- Yasemin Sancak 3 shared studies Showed as a Sabatini-lab graduate student, in parallel with Kun-Liang Guan's lab, that the Rag GTPases relay amino-acid signals to mTORC1, and that Ragulator anchors them to the lysosome where mTORC1 is switched on. She also identified PRAS40 as an insulin-regulated inhibitor of mTORC1
- Mathieu Laplante 2 shared studies Co-wrote with David Sabatini one of the field's most cited reviews of mTOR in growth and disease, and his Laval lab studies how mTORC1 and DEPTOR control fat tissue and metabolism
- Nathanael S. Gray 2 shared studies Medicinal chemist whose lab designed Torin1, an ATP-competitive mTOR inhibitor that blocks functions of mTORC1 that rapamycin misses. His lab is also known for covalent kinase inhibitors and targeted protein degraders
- Robert A Lindquist 2 shared studies Researcher in David Sabatini's group at the Whitehead Institute who ran large image-based RNAi screens for regulators of TORC1 signaling and helped build the CellProfiler image-analysis software
- David A. Guertin Built the mouse genetics that defined mTORC2's biological roles
- Kathleen Ottina Researcher in David Sabatini's lab at the Whitehead Institute and HHMI at MIT who contributed to studies of the GATOR1 amino acid off-switch, mTORC1 feedback on growth-factor signalling, and cancer drug resistance
- Liron Bar-Peled Showed as a Sabatini-lab graduate student that Ragulator switches the Rag GTPases on, acting as their GEF. He also discovered GATOR1 and GATOR2; GATOR1 switches the Rags off and its genes are mutated in some cancers
- Michael B. Yaffe Cancer biologist and physician-scientist known for working out how phosphorylation creates binding sites on proteins, including the 14-3-3 family of phosphoserine/threonine-binding proteins, and how kinases choose their targets.
- Peggy P. Hsu Identified, in parallel with Yonghao Yu's group, Grb10 as an mTORC1 substrate that feeds back to dampen insulin and growth-factor signalling, and now studies the earliest steps of lung cancer as a physician-scientist
- Shomit Sengupta Showed that mTORC1 controls whether the liver makes ketone bodies during fasting, and now leads biology for drug discovery at a metabolic-disease biotech
- W. Michael Kuehl Physician-scientist who spent decades working out the genetic and molecular biology of multiple myeloma and its precursor condition MGUS.
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