Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

Target of rapamycin (TOR) is an evolutionally conserved protein kinase in eukaryotes and a central cell growth controller. TOR exists in two distinct complexes, termed TORC1 and TORC2. Mammalian TORC2 has recently been shown to possess kinase activity toward the C-terminal hydrophobic site of Akt/PKB. Here, we report that Sin1 is an essential component of TORC2 but not of TORC1, and functions similarly to Rictor, the defining member of TORC2, in complex formation and kinase activity.

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Yang, Q., et al. (2006). Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes & development. https://doi.org/10.1101/gad.1461206

@article{YAN2006,
  author       = {Yang, Q. and Guan, K. L. and others},
  title        = {{Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity}},
  journal      = {Genes & development},
  year         = {2006},
  doi          = {10.1101/gad.1461206},
  note         = {PMID: 17043309},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record YAN2006) [Data set]. https://mtor-atlas.org/study/YAN2006/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_YAN2006,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record YAN2006},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/YAN2006/},
  doi          = {10.5281/zenodo.22059963}
}