Architecture of the human mTORC2 core complex

Stuttfeld E, Aylett CH, Imseng S, Boehringer D, Scaiola A, Sauer E, Hall MN, Maier T, Ban N · 2018 · eLife · Atlas ID STU2018

What this study shows

Architecture of the human mTORC2 core complex (mTOR-Rictor-SIN1-mLST8).

Abstract

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The mammalian target of rapamycin (mTOR) is a key protein kinase controlling cellular metabolism and growth. It is part of the two structurally and functionally distinct multiprotein complexes mTORC1 and mTORC2. Dysregulation of mTOR occurs in diabetes, cancer and neurological disease. We report the architecture of human mTORC2 at intermediate resolution, revealing a conserved binding site for accessory proteins on mTOR and explaining the structural basis for the rapamycin insensitivity of the complex.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cryo-EM structure) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Cryo-EM structure
Journal	eLife
Year	2018
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.7554/eLife.33101 · PMID 29424687 · Free full text (PMC5837792)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Structural (cryo-EM)
Target	mTORC2 core
Model	Cryo-EM structure
Effect	Architecture of the human mTORC2 core complex, revealing a conserved accessory-protein binding site

In the Atlas

Links in the pathway map

Supports mTOR required-for mTORC2
Supports SIN1 / MAPKAP1 required-for mTORC2

Cite this paper

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Stuttfeld, E., Aylett, C. H., Imseng, S., Boehringer, D., Scaiola, A., Sauer, E., Hall, M. N., Maier, T., & Ban, N. (2018). Architecture of the human mTORC2 core complex. eLife. https://doi.org/10.7554/eLife.33101

@article{STU2018,
  author       = {Stuttfeld, E. and Aylett, C. H. and Imseng, S. and Boehringer, D. and Scaiola, A. and Sauer, E. and Hall, M. N. and Maier, T. and Ban, N.},
  title        = {{Architecture of the human mTORC2 core complex}},
  journal      = {eLife},
  year         = {2018},
  doi          = {10.7554/eLife.33101},
  note         = {PMID: 29424687},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record STU2018) [Data set]. https://mtor-atlas.org/study/STU2018/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_STU2018,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record STU2018},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/STU2018/},
  doi          = {10.5281/zenodo.22059963}
}

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