Oliver's mTOR Atlas Evidence Platform
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Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: a pilot single-arm trial.

Aware C Neher CM Woods C Khegai O Dwivedi AK Govindarajan M Ivanich K Kurt M Beversdorf D Cheng J Bresette N Cui T Balchandani P Gonzales MM Ericsson AC Altes T Lin AL · 2026 · Journal of Cerebral Blood Flow and Metabolism · Atlas ID AWARE2026

What this study shows

Rare human trial of low-dose rapamycin as a geroprotector: genotype-dependent (APOE4 vs non-carrier) improvements in cerebral blood flow plus favorable metabolic, inflammatory, and gut-microbiome shifts in cognitively normal middle-aged adults before Alzheimer's pathology onset — extends rapamycin/longevity clinical-translation evidence with a precision-medicine angle.

At a glance

Evidence type H Human study Marked H because it is direct evidence from a human clinical trial or human cohort; the code names the kind of study, not its quality -- a small, well-run trial is still H.
Study type2 - Human Clinical Trial
Model systemHuman pilot single-arm trial, healthy middle-aged APOE4 carriers vs non-carriers
JournalJournal of Cerebral Blood Flow and Metabolism
Year2026
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1177/0271678X261490342 · PMID 42723264

Cite this paper

ShowHide 
Aware C
Neher CM
Woods C
Khegai O
Dwivedi AK
Govindarajan M
Ivanich K
Kurt M
Beversdorf D
Cheng J
Bresette N
Cui T
Balchandani P
Gonzales MM
Ericsson AC
Altes T
Lin AL (2026). Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: a pilot single-arm trial. Journal of Cerebral Blood Flow and Metabolism. https://doi.org/10.1177/0271678X261490342

@article{AWARE2026,
  author       = {Aware C
Neher CM
Woods C
Khegai O
Dwivedi AK
Govindarajan M
Ivanich K
Kurt M
Beversdorf D
Cheng J
Bresette N
Cui T
Balchandani P
Gonzales MM
Ericsson AC
Altes T
Lin AL},
  title        = {{Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: a pilot single-arm trial}},
  journal      = {Journal of Cerebral Blood Flow and Metabolism},
  year         = {2026},
  doi          = {10.1177/0271678X261490342},
  note         = {PMID: 42723264},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record AWARE2026) [Data set]. https://mtor-atlas.org/study/AWARE2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_AWARE2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record AWARE2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/AWARE2026/},
  doi          = {10.5281/zenodo.22059963}
}