Ai-Ling Lin
Neuroimaging scientist who studies brain blood flow and metabolism in ageing and Alzheimer's risk, including the effect of rapamycin in people who carry APOE4.
Professor and Vice Chair for Research, Department of Radiology, University of Missouri · NextGen Precision Health Investigator
Lin Lab, Department of Radiology, University of Missouri (Columbia, Missouri, USA) ↗
Portrait: University of Missouri School of Medicine
Ai-Ling Lin is a professor of radiology at the University of Missouri. Her page describes her as an expert in translational neuroimaging of brain vascular and metabolic function in ageing, which means using brain scans to study how blood flow and energy use change as we grow older.
Her group is interested in people who carry the APOE4 gene variant, which raises the risk of Alzheimer's disease and is linked to blood vessel changes in the brain years before symptoms appear.
In the pilot trial in this Atlas, 23 healthy adults aged 45 to 65 took 1 mg of rapamycin a day for four weeks. Brain blood flow rose by more than 15 percent in several regions in the nine APOE4 carriers, but not in non-carriers. It was a small study with no control group, so it points to an idea to test rather than a proven benefit.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2026 | H | Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: a pilot single-arm trial. AWARE2026 Single-arm pilot trial in which low-dose rapamycin raised cerebral blood flow in APOE4 carriers; Lin is the senior (last) author. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Ai-Ling Lin.
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- Chetan Aware Researcher in Ai-Ling Lin's group at the University of Missouri who studies how rapamycin and the gut microbiome affect brain blood flow and metabolism in people and mice at genetic risk of Alzheimer's disease
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