Oliver's mTOR Atlas Evidence Platform
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Molecular interplay between mTOR, amyloid-beta, and Tau: effects on cognitive impairments

Caccamo A, Majumder S, Richardson A, Strong R, Oddo S · 2010 · Journal of Biological Chemistry · Atlas ID CAC2010

What this study shows

Revealed a vicious cycle: amyloid-beta RAISES mTOR activity, and high mTOR in turn blocks the autophagy needed to clear amyloid and tau - so the disease feeds itself. Rapamycin broke the loop in 3xTg-AD mice, rescuing memory and lowering BOTH amyloid and tau, with autophagy shown to be required for the effect.

Abstract

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Accumulation of amyloid-beta (Abeta) and Tau is an invariant feature of Alzheimer disease (AD). The upstream role of Abeta accumulation in the disease pathogenesis is widely accepted, and there is strong evidence showing that Abeta accumulation causes cognitive impairments. However, the molecular mechanisms linking Abeta to cognitive decline remain to be elucidated. Here we show that the buildup of Abeta increases the mammalian target of rapamycin (mTOR) signaling, whereas decreasing mTOR signaling reduces Abeta levels, thereby highlighting an interrelation between mTOR signaling and Abeta.

Read the full abstract on PubMed →

At a glance

Evidence type A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: 3xTg-AD transgenic mice); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type4 - Animal Study
Model system3xTg-AD transgenic mice
JournalJournal of Biological Chemistry
Year2010
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1074/jbc.M110.100420 · PMID 20178983 · Free full text (PMC2857107)

Extracted findings

InterventionGenetic/pharmacologic (amyloid-β; mTOR)
TargetmTOR / amyloid-β / Tau
Model3xTg-AD transgenic mice
EffectAmyloid-β accumulation increases mTOR signaling, linking Aβ to cognitive impairment

In the Atlas

Related topics

RapamycinAlzheimer's diseasemTORC1Autophagy

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Cite this paper

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Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010). Molecular interplay between mTOR, amyloid-beta, and Tau: effects on cognitive impairments. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M110.100420

@article{CAC2010,
  author       = {Caccamo, A. and Majumder, S. and Richardson, A. and Strong, R. and Oddo, S.},
  title        = {{Molecular interplay between mTOR, amyloid-beta, and Tau: effects on cognitive impairments}},
  journal      = {Journal of Biological Chemistry},
  year         = {2010},
  doi          = {10.1074/jbc.M110.100420},
  note         = {PMID: 20178983},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record CAC2010) [Data set]. https://mtor-atlas.org/study/CAC2010/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_CAC2010,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record CAC2010},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/CAC2010/},
  doi          = {10.5281/zenodo.22059963}
}