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Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH, Zhang Y, Becker KG, Pérez VI, Richardson A · 2014 · PloS one · Atlas ID FOK2014

What this study shows

Rapamycin-fed mice show extended lifespan with major changes in the liver transcriptome.

Abstract

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Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin's longevity effect, we analyzed the transcriptome of liver from 25-month-old male and female mice fed rapamycin starting at 4 months of age. Few changes (<300 transcripts) were observed in transcriptome of rapamycin-fed males; however, a large number of transcripts (>4,500) changed significantly in females.

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At a glance

Evidence type A Animal model Marked A because it is an animal intervention or observation study measuring an organismal outcome (model: Mouse); the code names the system studied -- animal work can be rigorous and still not be human data.
Study type4 - Animal Study
Model systemMouse
JournalPloS one
Year2014
Peer reviewedYes
Record last updated2026-10-01
SourceDOI 10.1371/journal.pone.0083988 · PMID 24409289 · Free full text (PMC3883653)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

InterventionRapamycin (from 4 months of age)
TargetmTOR
ModelMouse (C57BL/6J)
EffectRapamycin increased lifespan 11-16% with major changes in the liver transcriptome
Dose14 ppm encapsulated rapamycin in food, ad libitum, starting at 4 months of age until end of life
Sample size175 mice total (40 control males, 45 Rapa males, 45 control females, 45 Rapa females)
Effect sizeRapamycin increased lifespan 16% in females and 11% in males (entire survival curve analysis), and significantly increased mean (14% females, 7% males) and maximum (19% females, 8% males) survival.
Limitationsnot stated

In the Atlas

Related topics

mTOR

Open questions that cite this study

Cite this paper

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Fok, W. C., Chen, Y., Bokov, A., Zhang, Y., Salmon, A. B., Diaz, V., Javors, M., Wood, W. H., Zhang, Y., Becker, K. G., Pérez, V. I., & Richardson, A. (2014). Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PloS one. https://doi.org/10.1371/journal.pone.0083988

@article{FOK2014,
  author       = {Fok, W. C. and Chen, Y. and Bokov, A. and Zhang, Y. and Salmon, A. B. and Diaz, V. and Javors, M. and Wood, W. H. and Zhang, Y. and Becker, K. G. and Pérez, V. I. and Richardson, A.},
  title        = {{Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome}},
  journal      = {PloS one},
  year         = {2014},
  doi          = {10.1371/journal.pone.0083988},
  note         = {PMID: 24409289},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record FOK2014) [Data set]. https://mtor-atlas.org/study/FOK2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_FOK2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record FOK2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/FOK2014/},
  doi          = {10.5281/zenodo.22059963}
}
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