Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome

Rapamycin was found to increase (11% to 16%) the lifespan of male and female C57BL/6J mice most likely by reducing the increase in the hazard for mortality (i.e., the rate of aging) term in the Gompertz mortality analysis. To identify the pathways that could be responsible for rapamycin's longevity effect, we analyzed the transcriptome of liver from 25-month-old male and female mice fed rapamycin starting at 4 months of age. Few changes (<300 transcripts) were observed in transcriptome of rapamycin-fed males; however, a large number of transcripts (>4,500) changed significantly in females.

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Fok, W. C., et al. (2014). Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome. PloS one. https://doi.org/10.1371/journal.pone.0083988

@article{FOK2014,
  author       = {Fok, W. C. and Richardson, A. and others},
  title        = {{Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome}},
  journal      = {PloS one},
  year         = {2014},
  doi          = {10.1371/journal.pone.0083988},
  note         = {PMID: 24409289},
}

Cite this Atlas record

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Barton, O. (2026). Oliver's mTOR Atlas (record FOK2014) [Data set]. https://mtor-atlas.org/study/FOK2014/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_FOK2014,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record FOK2014},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/FOK2014/},
  doi          = {10.5281/zenodo.22059963}
}