Wilson C. Fok
Biologist of aging who, in Viviana Pérez's group in San Antonio, compared rapamycin with dietary restriction in mouse liver and showed that rapamycin's lifespan gain comes with large changes in liver gene activity
Department of Cellular and Structural Biology and Barshop Institute for Longevity and Aging Studies, UT Health San Antonio (papers 2012–2015, at the time of the study)
Wilson Fok is first author of the Atlas study FOK2014, with A. Richardson as senior author. Mice fed rapamycin in their food lived longer, and their livers showed large changes in which genes were turned on or off, measured across the whole transcriptome. The study helped connect rapamycin's effect on lifespan with concrete changes in an organ that controls much of the body's metabolism. It is a mouse study.
Fok's other first-author papers from San Antonio, with Viviana Pérez, compared rapamycin with dietary restriction, the best-known way to extend lifespan in lab animals. Short-term treatment in young mice showed that the two had overlapping but distinct effects (2012), and combining them changed the liver transcriptome and metabolome more than either alone (2013). Fok was also a co-author on a 2014 study showing that rapamycin and dietary restriction cause metabolically distinct changes in mouse liver.
In 2015 Fok is listed at the Barshop Institute on a study of a mitochondrial protease in muscle cells. No later position could be confirmed from sources that tie directly to this work, so the affiliation shown is the one on the Atlas paper.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2014 | A | Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome FOK2014 First author: showed that rapamycin-fed mice lived longer and had large changes in the liver transcriptome. |
Co-authors in the Atlas 3
People with a profile here who share at least one study with Wilson C. Fok.
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- Adam B. Salmon Biologist of aging at UT Health San Antonio whose work in this Atlas spans rapamycin in mice and in common marmosets. He is a co-author on the Interventions Testing Program reports from the San Antonio site and on the marmoset rapamycin studies on blood markers, epigenetic age and the salivary gland
- Arlan Richardson Studies how rapamycin slows ageing in mice, including the broad changes it causes in the liver, and co-authored early studies showing that rapamycin protects memory in Alzheimer's-model mice
- Vivian Diaz Aging researcher at the Barshop Institute in San Antonio who has worked for more than a decade on the mouse lifespan studies behind rapamycin's reputation as an anti-aging drug, including the Interventions Testing Program
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