mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

In response to growth signals, mechanistic target of rapamycin complex 1 (mTORC1) stimulates anabolic processes underlying cell growth. We found that mTORC1 increases metabolic flux through the de novo purine synthesis pathway in various mouse and human cells, thereby influencing the nucleotide pool available for nucleic acid synthesis.

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Ben-Sahra, I., et al. (2016). mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science. https://doi.org/10.1126/science.aad0489

@article{BEN2016,
  author       = {Ben-Sahra, I. and Manning, B. D. and others},
  title        = {{mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle}},
  journal      = {Science},
  year         = {2016},
  doi          = {10.1126/science.aad0489},
  note         = {PMID: 26912861},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BEN2016) [Data set]. https://mtor-atlas.org/study/BEN2016/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BEN2016,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BEN2016},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BEN2016/},
  doi          = {10.5281/zenodo.22059963}
}