Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1

Cellular growth signals stimulate anabolic processes. The mechanistic target of rapamycin complex 1 (mTORC1) is a protein kinase that senses growth signals to regulate anabolic growth and proliferation. Activation of mTORC1 led to the acute stimulation of metabolic flux through the de novo pyrimidine synthesis pathway.

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Ben-Sahra, I., et al. (2013). Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science. https://doi.org/10.1126/science.1228792

@article{BEN2013,
  author       = {Ben-Sahra, I. and Manning, B. D. and others},
  title        = {{Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1}},
  journal      = {Science},
  year         = {2013},
  doi          = {10.1126/science.1228792},
  note         = {PMID: 23429703},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record BEN2013) [Data set]. https://mtor-atlas.org/study/BEN2013/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_BEN2013,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record BEN2013},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/BEN2013/},
  doi          = {10.5281/zenodo.22059963}
}