Twenty-five years of mTOR: Uncovering the link from nutrients to growth

In my PNAS Inaugural Article, I describe the development of the mTOR field, starting with efforts to understand the mechanism of action of the drug rapamycin, which ~25 y ago led to the discovery of the mTOR protein kinase. I focus on insights that we have contributed and on work that has been particularly influential to me, as well as provide some personal reflections and stories.

Read the full abstract on PubMed →

Sabatini, D. M. (2017). Twenty-five years of mTOR: Uncovering the link from nutrients to growth. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1716173114

@article{SAB2017,
  author       = {Sabatini, D. M.},
  title        = {{Twenty-five years of mTOR: Uncovering the link from nutrients to growth}},
  journal      = {Proceedings of the National Academy of Sciences of the United States of America},
  year         = {2017},
  doi          = {10.1073/pnas.1716173114},
  note         = {PMID: 29078414},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SAB2017) [Data set]. https://mtor-atlas.org/study/SAB2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SAB2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SAB2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SAB2017/},
  doi          = {10.5281/zenodo.22059963}
}