Twenty-five years of mTOR: Uncovering the link from nutrients to growth

Sabatini DM · 2017 · Proceedings of the National Academy of Sciences of the United States of America · Atlas ID SAB2017

What this study shows

Sabatini's 25-year synthesis linking nutrient sensing to growth through mTOR.

Abstract

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In my PNAS Inaugural Article, I describe the development of the mTOR field, starting with efforts to understand the mechanism of action of the drug rapamycin, which ~25 y ago led to the discovery of the mTOR protein kinase. I focus on insights that we have contributed and on work that has been particularly influential to me, as well as provide some personal reflections and stories.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Proceedings of the National Academy of Sciences of the United States of America
Year	2017
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1073/pnas.1716173114 · PMID 29078414 · Free full text (PMC5692607)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (historical review)
Target	mTOR
Model	Review
Effect	Personal historical account of the mTOR field from rapamycin's mechanism to discovery of the mTOR kinase

In the Atlas

Cite this paper

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Sabatini, D. M. (2017). Twenty-five years of mTOR: Uncovering the link from nutrients to growth. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1716173114

@article{SAB2017,
  author       = {Sabatini, D. M.},
  title        = {{Twenty-five years of mTOR: Uncovering the link from nutrients to growth}},
  journal      = {Proceedings of the National Academy of Sciences of the United States of America},
  year         = {2017},
  doi          = {10.1073/pnas.1716173114},
  note         = {PMID: 29078414},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SAB2017) [Data set]. https://mtor-atlas.org/study/SAB2017/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SAB2017,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SAB2017},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SAB2017/},
  doi          = {10.5281/zenodo.22059963}
}

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