mTOR at the nexus of nutrition, growth, ageing and disease

The mTOR pathway integrates a diverse set of environmental cues, such as growth factor signals and nutritional status, to direct eukaryotic cell growth. Over the past two and a half decades, mapping of the mTOR signalling landscape has revealed that mTOR controls biomass accumulation and metabolism by modulating key cellular processes, including protein synthesis and autophagy. Given the pathway's central role in maintaining cellular and physiological homeostasis, dysregulation of mTOR signalling has been implicated in metabolic disorders, neurodegeneration, cancer and ageing.

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Liu, G. Y., & Sabatini, D. M. (2020). mTOR at the nexus of nutrition, growth, ageing and disease. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/s41580-019-0199-y

@article{LIU2020,
  author       = {Liu, G. Y. and Sabatini, D. M.},
  title        = {{mTOR at the nexus of nutrition, growth, ageing and disease}},
  journal      = {Nature Reviews Molecular Cell Biology},
  year         = {2020},
  doi          = {10.1038/s41580-019-0199-y},
  note         = {PMID: 31937935},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LIU2020) [Data set]. https://mtor-atlas.org/study/LIU2020/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LIU2020,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LIU2020},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LIU2020/},
  doi          = {10.5281/zenodo.22059963}
}