mTOR signaling in growth control and disease

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation.

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Laplante, M., & Sabatini, D. M. (2012). mTOR signaling in growth control and disease. Cell. https://doi.org/10.1016/j.cell.2012.03.017

@article{LAP2012,
  author       = {Laplante, M. and Sabatini, D. M.},
  title        = {{mTOR signaling in growth control and disease}},
  journal      = {Cell},
  year         = {2012},
  doi          = {10.1016/j.cell.2012.03.017},
  note         = {PMID: 22500797},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record LAP2012) [Data set]. https://mtor-atlas.org/study/LAP2012/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_LAP2012,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record LAP2012},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/LAP2012/},
  doi          = {10.5281/zenodo.22059963}
}