Regulation and metabolic functions of mTORC1 and mTORC2

Szwed A, Kim E, Jacinto E · 2021 · Physiological reviews · Atlas ID SZW2021

What this study shows

Comprehensive review of the regulation and metabolic functions of mTORC1 and mTORC2.

Abstract

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Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves cross talk between growth signaling and metabolic pathways. Despite constant fluctuations in nutrient availability and environmental signals, normal cells restore metabolic homeostasis to maintain cellular functions and prevent disease. A central signaling molecule that integrates growth with metabolism is the mechanistic target of rapamycin (mTOR).

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Physiological reviews
Year	2021
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1152/physrev.00026.2020 · PMID 33599151 · Free full text (PMC8424549)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	mTORC1 / mTORC2
Model	Review
Effect	Reviews how mTORC1/2 integrate growth signaling with metabolism

In the Atlas

Cite this paper

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Szwed, A., Kim, E., & Jacinto, E. (2021). Regulation and metabolic functions of mTORC1 and mTORC2. Physiological reviews. https://doi.org/10.1152/physrev.00026.2020

@article{SZW2021,
  author       = {Szwed, A. and Kim, E. and Jacinto, E.},
  title        = {{Regulation and metabolic functions of mTORC1 and mTORC2}},
  journal      = {Physiological reviews},
  year         = {2021},
  doi          = {10.1152/physrev.00026.2020},
  note         = {PMID: 33599151},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SZW2021) [Data set]. https://mtor-atlas.org/study/SZW2021/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SZW2021,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SZW2021},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SZW2021/},
  doi          = {10.5281/zenodo.22059963}
}

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