Regulation and metabolic functions of mTORC1 and mTORC2

Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves cross talk between growth signaling and metabolic pathways. Despite constant fluctuations in nutrient availability and environmental signals, normal cells restore metabolic homeostasis to maintain cellular functions and prevent disease. A central signaling molecule that integrates growth with metabolism is the mechanistic target of rapamycin (mTOR).

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Szwed, A., et al. (2021). Regulation and metabolic functions of mTORC1 and mTORC2. Physiological reviews. https://doi.org/10.1152/physrev.00026.2020

@article{SZW2021,
  author       = {Szwed, A. and Jacinto, E. and others},
  title        = {{Regulation and metabolic functions of mTORC1 and mTORC2}},
  journal      = {Physiological reviews},
  year         = {2021},
  doi          = {10.1152/physrev.00026.2020},
  note         = {PMID: 33599151},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record SZW2021) [Data set]. https://mtor-atlas.org/study/SZW2021/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_SZW2021,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record SZW2021},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/SZW2021/},
  doi          = {10.5281/zenodo.22059963}
}