Pungenin Promotes Hair Growth in Mouse Models of Androgenic Alopecia Through Transcriptional Regulation of the PI3K/AKT/mTOR Axis.

Androgenetic alopecia (AGA) is characterized by progressive miniaturization of hair follicles driven by dihydrotestosterone (DHT)-mediated androgen receptor signalling. Pungenin, a phenolic glucoside, was investigated in DHT-induced AGA model mice. In primary mouse hair follicle cells exposed to DHT, pungenin mitigated cellular injury, restored morphology and viability, and significantly reduced type II 5alpha-reductase expression. Topical pungenin markedly accelerated hair regeneration by histological analysis and serum biochemistry.

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Zhai, W., et al. (2026). Pungenin Promotes Hair Growth in Mouse Models of Androgenic Alopecia Through Transcriptional Regulation of the PI3K/AKT/mTOR Axis. Molecules. https://doi.org/10.3390/molecules31162864

@article{ZHAI2026,
  author       = {Zhai, W. and Yang, J. and Zhang, L. and others},
  title        = {{Pungenin Promotes Hair Growth in Mouse Models of Androgenic Alopecia Through Transcriptional Regulation of the PI3K/AKT/mTOR Axis}},
  journal      = {Molecules},
  year         = {2026},
  doi          = {10.3390/molecules31162864},
  note         = {PMID: 42653946},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ZHAI2026) [Data set]. https://mtor-atlas.org/study/ZHAI2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ZHAI2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ZHAI2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ZHAI2026/},
  doi          = {10.5281/zenodo.22059963}
}