Regulation of TORC1 by Rag GTPases in nutrient response

Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL · 2008 · Nature cell biology · Atlas ID KIM2008

What this study shows

Rag GTPases mediate amino-acid signalling to TORC1 (parallel discovery to Sancak 2008).

Abstract

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TORC1 (target of rapamycin complex 1) has a crucial role in the regulation of cell growth and size. A wide range of signals, including amino acids, is known to activate TORC1. Here, we report the identification of Rag GTPases as activators of TORC1 in response to amino acid signals. Knockdown of Rag gene expression suppressed the stimulatory effect of amino acids on TORC1 in Drosophila melanogaster S2 cells.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Nature cell biology
Year	2008
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/ncb1753 · PMID 18604198 · Free full text (PMC2711503)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic/biochemical (Rag GTPases)
Target	TORC1 / Rag GTPases
Model	Mammalian cells (+ Drosophila S2)
Effect	Rag GTPases activate TORC1 in response to amino-acid signals

In the Atlas

Links in the pathway map

Supports Rag GTPases recruits mTORC1

Cite this paper

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Kim, E., Goraksha-Hicks, P., Li, L., Neufeld, T. P., & Guan, K. L. (2008). Regulation of TORC1 by Rag GTPases in nutrient response. Nature cell biology. https://doi.org/10.1038/ncb1753

@article{KIM2008,
  author       = {Kim, E. and Goraksha-Hicks, P. and Li, L. and Neufeld, T. P. and Guan, K. L.},
  title        = {{Regulation of TORC1 by Rag GTPases in nutrient response}},
  journal      = {Nature cell biology},
  year         = {2008},
  doi          = {10.1038/ncb1753},
  note         = {PMID: 18604198},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record KIM2008) [Data set]. https://mtor-atlas.org/study/KIM2008/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_KIM2008,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record KIM2008},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/KIM2008/},
  doi          = {10.5281/zenodo.22059963}
}

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