Thomas P. Neufeld
Uses Drosophila to study how TOR signalling controls cell growth and autophagy; his group was one of two that described the fly TOR gene in 2000
Professor, Department of Genetics, Cell Biology and Development, University of Minnesota
Portrait: University of Minnesota, College of Biological Sciences
Thomas Neufeld was the senior and corresponding author of the Atlas study showing that fly TOR (dTOR) is needed inside each cell for normal growth and for the extra growth driven by PI3K, and that extra S6 kinase can rescue dTOR mutant flies (ZHA2000). The work was a collaboration with researchers at Chiron Corporation and appeared in the same journal issue as a parallel dTOR study from the Hafen and Thomas groups (OLD2000).
At the University of Minnesota his lab studies how nutrients and growth factors control cell growth through TOR, and how TOR regulates autophagy, the recycling of cell contents during starvation, using the fruit fly as a model.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2000 | M | Regulation of cellular growth by the Drosophila target of rapamycin dTOR ZHA2000 Senior author: showed that dTOR is needed cell-autonomously for growth in Drosophila larvae and that S6 kinase overexpression rescues dTOR mutants. |
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