Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag-, Ragulator-, and vacuolar adenosine triphosphatase-dependent fashion, the translocation of mTORC1 to the lysosomal surface, where it interacts with its activator Rheb.

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Wang, S., et al. (2015). Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. https://doi.org/10.1126/science.1257132

@article{WAN2015,
  author       = {Wang, S. and Sabatini, D. M. and others},
  title        = {{Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1}},
  journal      = {Science},
  year         = {2015},
  doi          = {10.1126/science.1257132},
  note         = {PMID: 25567906},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WAN2015) [Data set]. https://mtor-atlas.org/study/WAN2015/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WAN2015,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WAN2015},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WAN2015/},
  doi          = {10.5281/zenodo.22059963}
}