Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, …, Sabatini DM · 2015 · Science · Atlas ID WAN2015

What this study shows

The lysosomal transporter SLC38A9 signals arginine sufficiency to mTORC1.

Abstract

ShowHide

The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids stimulate, in a Rag-, Ragulator-, and vacuolar adenosine triphosphatase-dependent fashion, the translocation of mTORC1 to the lysosomal surface, where it interacts with its activator Rheb.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Science
Year	2015
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1126/science.1257132 · PMID 25567906 · Free full text (PMC4295826)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical/genetic (SLC38A9)
Target	SLC38A9 / Rag-Ragulator / mTORC1
Model	Mammalian cells
Effect	SLC38A9 signals arginine sufficiency to mTORC1 at the lysosomal surface

In the Atlas

Links in the pathway map

Supports SLC38A9 activates Rag GTPases

Cite this paper

ShowHide

Wang, S., Tsun, Z. Y., Wolfson, R. L., Shen, K., Wyant, G. A., Plovanich, M. E., Yuan, E. D., Jones, T. D., Chantranupong, L., Comb, W., Wang, T., Bar-Peled, L., Zoncu, R., Straub, C., Kim, C., Park, J., Sabatini, B. L., & Sabatini, D. M. (2015). Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. https://doi.org/10.1126/science.1257132

@article{WAN2015,
  author       = {Wang, S. and Tsun, Z. Y. and Wolfson, R. L. and Shen, K. and Wyant, G. A. and Plovanich, M. E. and Yuan, E. D. and Jones, T. D. and Chantranupong, L. and Comb, W. and Wang, T. and Bar-Peled, L. and Zoncu, R. and Straub, C. and Kim, C. and Park, J. and Sabatini, B. L. and Sabatini, D. M.},
  title        = {{Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1}},
  journal      = {Science},
  year         = {2015},
  doi          = {10.1126/science.1257132},
  note         = {PMID: 25567906},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record WAN2015) [Data set]. https://mtor-atlas.org/study/WAN2015/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_WAN2015,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record WAN2015},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/WAN2015/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?