Oliver's mTOR Atlas Evidence Platform
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SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Rebsamen M, Superti-Furga G et al. · 2015 · Nature · Atlas ID REB2015

What this study shows

SLC38A9 is a component of the lysosomal amino-acid sensing machinery controlling mTORC1.

Abstract

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Cell growth and proliferation are tightly linked to nutrient availability. The mechanistic target of rapamycin complex 1 (mTORC1) integrates the presence of growth factors, energy levels, glucose and amino acids to modulate metabolic status and cellular responses. mTORC1 is activated at the surface of lysosomes by the RAG GTPases and the Ragulator complex through a not fully understood mechanism monitoring amino acid availability in the lysosomal lumen and involving the vacuolar H(+)-ATPase.

Read the full abstract on PubMed →

At a glance

Evidence type M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type5 - Mechanistic / In Vitro
Model systemMammalian cells
JournalNature
Year2015
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1038/nature14107 · PMID 25561175 · Free full text (PMC4376665)

Extracted findings

InterventionBiochemical/genetic (SLC38A9)
TargetSLC38A9 / Rag-Ragulator / mTORC1
ModelMammalian cells
EffectSLC38A9 is a lysosomal amino-acid (arginine) transporter/sensor component that controls mTORC1

In the Atlas

Related topics

ArginineSLC38A9

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Cite this paper

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Rebsamen, M., et al. (2015). SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Nature. https://doi.org/10.1038/nature14107

@article{REB2015,
  author       = {Rebsamen, M. and Superti-Furga, G. and others},
  title        = {{SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1}},
  journal      = {Nature},
  year         = {2015},
  doi          = {10.1038/nature14107},
  note         = {PMID: 25561175},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record REB2015) [Data set]. https://mtor-atlas.org/study/REB2015/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_REB2015,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record REB2015},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/REB2015/},
  doi          = {10.5281/zenodo.22059963}
}