Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

The serine/threonine kinase mTORC1 regulates cellular homeostasis in response to many cues, such as nutrient status and energy level. Amino acids induce mTORC1 activation on lysosomes via the small Rag GTPases and the Ragulator complex, thereby controlling protein translation and cell growth. Here, we identify the human 11-pass transmembrane protein SLC38A9 as a novel component of the Rag-Ragulator complex. SLC38A9 localizes with Rag-Ragulator complex components on lysosomes and associates with Rag GTPases in an amino acid-sensitive and nucleotide binding state-dependent manner.

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Jung, J., et al. (2015). Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9. Molecular and cellular biology. https://doi.org/10.1128/MCB.00125-15

@article{JUN2015,
  author       = {Jung, J. and Behrends, C. and others},
  title        = {{Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9}},
  journal      = {Molecular and cellular biology},
  year         = {2015},
  doi          = {10.1128/MCB.00125-15},
  note         = {PMID: 25963655},
}

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The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record JUN2015) [Data set]. https://mtor-atlas.org/study/JUN2015/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_JUN2015,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record JUN2015},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/JUN2015/},
  doi          = {10.5281/zenodo.22059963}
}