Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9

Jung J, Genau HM, Behrends C · 2015 · Molecular and cellular biology · Atlas ID JUN2015

What this study shows

SLC38A9, a lysosomal membrane protein, mediates amino-acid-dependent mTORC1 activation.

Abstract

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The serine/threonine kinase mTORC1 regulates cellular homeostasis in response to many cues, such as nutrient status and energy level. Amino acids induce mTORC1 activation on lysosomes via the small Rag GTPases and the Ragulator complex, thereby controlling protein translation and cell growth. Here, we identify the human 11-pass transmembrane protein SLC38A9 as a novel component of the Rag-Ragulator complex. SLC38A9 localizes with Rag-Ragulator complex components on lysosomes and associates with Rag GTPases in an amino acid-sensitive and nucleotide binding state-dependent manner.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Mammalian cells) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Mammalian cells
Journal	Molecular and cellular biology
Year	2015
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1128/MCB.00125-15 · PMID 25963655 · Free full text (PMC4475919)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Biochemical/genetic (SLC38A9)
Target	SLC38A9 / Rag-Ragulator / mTORC1
Model	Mammalian cells
Effect	SLC38A9 is a lysosomal component of the Rag-Ragulator that mediates amino-acid-dependent mTORC1 activation

In the Atlas

Links in the pathway map

Supports SLC38A9 activates Rag GTPases

Cite this paper

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Jung, J., Genau, H. M., & Behrends, C. (2015). Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9. Molecular and cellular biology. https://doi.org/10.1128/MCB.00125-15

@article{JUN2015,
  author       = {Jung, J. and Genau, H. M. and Behrends, C.},
  title        = {{Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9}},
  journal      = {Molecular and cellular biology},
  year         = {2015},
  doi          = {10.1128/MCB.00125-15},
  note         = {PMID: 25963655},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record JUN2015) [Data set]. https://mtor-atlas.org/study/JUN2015/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_JUN2015,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record JUN2015},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/JUN2015/},
  doi          = {10.5281/zenodo.22059963}
}

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