Jennifer Jung
Biochemist from Christian Behrends' group in Frankfurt who showed that the lysosomal amino acid transporter SLC38A9 helps switch on mTORC1, and who studied regulators of autophagy
Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt (papers 2015–2019, Christian Behrends group; at the time of the study)
Jennifer Jung is first author of an Atlas study (JUN2015) in human cells about SLC38A9, a protein in the membrane of the lysosome, the cell's recycling compartment. mTORC1, the growth-control complex, is switched on at the lysosome surface when amino acids are plentiful, with the help of the Rag GTPases and a scaffold called Ragulator. The study found SLC38A9 bound to the Rags and Ragulator. Removing SLC38A9 weakened mTORC1 activation by amino acids, and adding extra SLC38A9 made mTORC1 overactive. The same year two other groups reported similar findings, and SLC38A9 became known as a lysosomal arginine sensor for mTORC1.
Jung did this work in Christian Behrends' group at the Institute of Biochemistry II of Goethe University Frankfurt, which uses proteomics, the large-scale study of proteins and their partners, to map how autophagy and lysosomes are controlled. As first author of a 2017 eLife paper, Jung used an image-based RNAi screen to find autophagy regulators and showed that SMCR8, a partner of the ALS-linked protein C9ORF72, acts as a brake on the autophagy kinase ULK1. The publication record with the Behrends group runs from 2015 to 2019. Later positions could not be confirmed.
Milestones in the Atlas
A selection, not a full bibliography: only papers that meet the Atlas inclusion criteria.
| Year | Evidence | Study |
|---|---|---|
| 2015 | M | Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9 JUN2015 First author: showed that the lysosomal protein SLC38A9 binds the Rag-Ragulator machinery and is needed for full amino acid activation of mTORC1. |
Co-authors in the Atlas 1
People with a profile here who share at least one study with Jennifer Jung.
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- Christian Behrends Studies autophagy and ubiquitin pathways, and in 2015 reported SLC38A9 as a member of the Rag-Ragulator complex that relays amino acid availability to mTORC1.
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