The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism

Hoxhaj G, Manning BD · 2019 · Nature reviews. Cancer · Atlas ID HOX2019

What this study shows

Review of the PI3K-AKT-mTOR network at the interface of oncogenic signalling and metabolism.

Abstract

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The altered metabolic programme of cancer cells facilitates their cell-autonomous proliferation and survival. In normal cells, signal transduction pathways control core cellular functions, including metabolism, to couple the signals from exogenous growth factors, cytokines or hormones to adaptive changes in cell physiology.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	Review
Journal	Nature reviews. Cancer
Year	2019
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1038/s41568-019-0216-7 · PMID 31686003 · Free full text (PMC7314312)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Not applicable (review)
Target	PI3K-AKT (upstream of mTOR)
Model	Review
Effect	Reviews the PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism

In the Atlas

Cite this paper

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Hoxhaj, G., & Manning, B. D. (2019). The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism. Nature reviews. Cancer. https://doi.org/10.1038/s41568-019-0216-7

@article{HOX2019,
  author       = {Hoxhaj, G. and Manning, B. D.},
  title        = {{The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism}},
  journal      = {Nature reviews. Cancer},
  year         = {2019},
  doi          = {10.1038/s41568-019-0216-7},
  note         = {PMID: 31686003},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record HOX2019) [Data set]. https://mtor-atlas.org/study/HOX2019/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HOX2019,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HOX2019},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HOX2019/},
  doi          = {10.5281/zenodo.22059963}
}

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