Structural basis for the docking of mTORC1 on the lysosomal surface

Rogala KB, Sabatini DM et al. · 2019 · Science · Atlas ID ROG2019

What this study shows

Structure shows how mTORC1 docks onto the Rag-Ragulator lysosomal scaffold.

Abstract

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The mTORC1 (mechanistic target of rapamycin complex 1) protein kinase regulates growth in response to nutrients and growth factors. Nutrients promote its translocation to the lysosomal surface, where its Raptor subunit interacts with the Rag guanosine triphosphatase (GTPase)-Ragulator complex. Nutrients switch the heterodimeric Rag GTPases among four different nucleotide-binding states, only one of which (RagA/B GTP-RagC/D GDP) permits mTORC1 association.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Cryo-EM structure) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Cryo-EM structure
Journal	Science
Year	2019
Peer reviewed	Yes
Record last updated	2026-08-22
Source	DOI 10.1126/science.aay0166 · PMID 31601708 · Free full text (PMC7176403)

Extracted findings

Intervention	Structural (cryo-EM)
Target	mTORC1 / Raptor / Rag-Ragulator
Model	Cryo-EM structure
Effect	Structure reveals how mTORC1 (via Raptor) docks on the Rag-Ragulator at the lysosomal surface

In the Atlas

Learn the biology

Want to understand the biology behind this study? → The Lysosome as a Signalling Platform

Cite this paper

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Rogala, K. B., et al. (2019). Structural basis for the docking of mTORC1 on the lysosomal surface. Science. https://doi.org/10.1126/science.aay0166

@article{ROG2019,
  author       = {Rogala, K. B. and Sabatini, D. M. and others},
  title        = {{Structural basis for the docking of mTORC1 on the lysosomal surface}},
  journal      = {Science},
  year         = {2019},
  doi          = {10.1126/science.aay0166},
  note         = {PMID: 31601708},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record ROG2019) [Data set]. https://mtor-atlas.org/study/ROG2019/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_ROG2019,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record ROG2019},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/ROG2019/},
  doi          = {10.5281/zenodo.22059963}
}