Extension of chronological life span in yeast by decreased TOR pathway signaling

Chronological life span (CLS) in Saccharomyces cerevisiae, defined as the time cells in a stationary phase culture remain viable, has been proposed as a model for the aging of post-mitotic tissues in mammals. We developed a high-throughput assay to determine CLS for approximately 4800 single-gene deletion strains of yeast, and identified long-lived strains carrying mutations in the conserved TOR pathway.

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Powers, R. W., et al. (2006). Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes & development. https://doi.org/10.1101/gad.1381406

@article{POW2006,
  author       = {Powers, R. W. and Fields, S. and others},
  title        = {{Extension of chronological life span in yeast by decreased TOR pathway signaling}},
  journal      = {Genes & development},
  year         = {2006},
  doi          = {10.1101/gad.1381406},
  note         = {PMID: 16418483},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record POW2006) [Data set]. https://mtor-atlas.org/study/POW2006/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_POW2006,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record POW2006},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/POW2006/},
  doi          = {10.5281/zenodo.22059963}
}