Extension of chronological life span in yeast by decreased TOR pathway signaling

Powers RW, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S · 2006 · Genes & development · Atlas ID POW2006

What this study shows

Decreased TOR pathway signalling extends chronological lifespan in yeast.

Abstract

ShowHide

Chronological life span (CLS) in Saccharomyces cerevisiae, defined as the time cells in a stationary phase culture remain viable, has been proposed as a model for the aging of post-mitotic tissues in mammals. We developed a high-throughput assay to determine CLS for approximately 4800 single-gene deletion strains of yeast, and identified long-lived strains carrying mutations in the conserved TOR pathway.

Read the full abstract on PubMed →

At a glance

Evidence type	M Molecular — cells, biochemistry, structure Marked M because it is molecular or in-vitro work (model: Yeast (S. cerevisiae)) rather than a whole-organism health-outcome study. That is often exactly where causal biology gets established -- the code says which system the finding was shown in, and nothing about how good the work is.
Study type	5 - Mechanistic / In Vitro
Model system	Yeast (S. cerevisiae)
Journal	Genes & development
Year	2006
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1101/gad.1381406 · PMID 16418483 · Free full text (PMC1356109)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	Genetic (TOR pathway deletions)
Target	TOR / Sch9
Model	Yeast (S. cerevisiae)
Effect	Decreased TOR pathway signaling extends yeast chronological lifespan

In the Atlas

Links in the pathway map

Supports mTORC1 inhibits Longevity

Cite this paper

ShowHide

Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006). Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes & development. https://doi.org/10.1101/gad.1381406

@article{POW2006,
  author       = {Powers, R. W. and Kaeberlein, M. and Caldwell, S. D. and Kennedy, B. K. and Fields, S.},
  title        = {{Extension of chronological life span in yeast by decreased TOR pathway signaling}},
  journal      = {Genes & development},
  year         = {2006},
  doi          = {10.1101/gad.1381406},
  note         = {PMID: 16418483},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record POW2006) [Data set]. https://mtor-atlas.org/study/POW2006/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_POW2006,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record POW2006},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/POW2006/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?