mTORC1, the maestro of cell metabolism and growth

He L, Cho S, Blenis J · 2025 · Genes & Development · Atlas ID HE2025

What this study shows

Comprehensive current review of how nutrients and growth signals are integrated by mTORC1 and the metabolic programs it commands, plus the clinical outlook for mTORC1-targeted therapy across cancer, neurodegeneration, obesity, diabetes and aging -- anchor reference for the pathway map.

Abstract

ShowHide

The mechanistic target of rapamycin (mTOR) pathway senses and integrates various environmental and intracellular cues to regulate cell growth and proliferation. As a key conductor of the balance between anabolic and catabolic processes, mTOR complex 1 (mTORC1) orchestrates the symphonic regulation of glycolysis, nucleic acid and lipid metabolism, protein translation and degradation, and gene expression. Dysregulation of the mTOR pathway is linked to numerous human diseases, including cancer, neurodegenerative disorders, obesity, diabetes, and aging.

Read the full abstract on PubMed →

At a glance

Evidence type	R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study type	Narrative Review
Model system	N/A (narrative review)
Journal	Genes & Development
Year	2025
Peer reviewed	Yes
Record last updated	2026-10-01
Source	DOI 10.1101/gad.352084.124 · PMID 39572234 · Free full text (PMC11789495)

Extracted findings

These fields were extracted from the paper with AI assistance and have not been checked against the source. Read them as a pointer into the paper, not as curated claims; where they disagree with the curated summary above, the curated summary stands.

Intervention	N/A (review)
Target	mTORC1 pathway (nutrient/growth factor integration)
Model	N/A
Effect	Comprehensive review of mTORC1 regulation, metabolic control, and clinical outlook

In the Atlas

Cite this paper

ShowHide

He, L., Cho, S., & Blenis, J. (2025). mTORC1, the maestro of cell metabolism and growth. Genes & Development. https://doi.org/10.1101/gad.352084.124

@article{HE2025,
  author       = {He, L. and Cho, S. and Blenis, J.},
  title        = {{mTORC1, the maestro of cell metabolism and growth}},
  journal      = {Genes & Development},
  year         = {2025},
  doi          = {10.1101/gad.352084.124},
  note         = {PMID: 39572234},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record HE2025) [Data set]. https://mtor-atlas.org/study/HE2025/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HE2025,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HE2025},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HE2025/},
  doi          = {10.5281/zenodo.22059963}
}

Was this page useful?