Oliver's mTOR Atlas Evidence Platform
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mTORC1, the maestro of cell metabolism and growth

He L, Cho S, Blenis J · 2025 · Genes & Development · Atlas ID HE2025

What this study shows

Comprehensive current review of how nutrients and growth signals are integrated by mTORC1 and the metabolic programs it commands, plus the clinical outlook for mTORC1-targeted therapy across cancer, neurodegeneration, obesity, diabetes and aging -- anchor reference for the pathway map.

Abstract

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The mechanistic target of rapamycin (mTOR) pathway senses and integrates various environmental and intracellular cues to regulate cell growth and proliferation. As a key conductor of the balance between anabolic and catabolic processes, mTOR complex 1 (mTORC1) orchestrates the symphonic regulation of glycolysis, nucleic acid and lipid metabolism, protein translation and degradation, and gene expression. Dysregulation of the mTOR pathway is linked to numerous human diseases, including cancer, neurodegenerative disorders, obesity, diabetes, and aging.

Read the full abstract on PubMed →

At a glance

Evidence type R Review — secondary literature, not a new result Marked R because it is a review or synthesis of existing evidence rather than a new primary result; that is a different form of writing, not a weaker one.
Study typeNarrative Review
Model systemN/A (narrative review)
JournalGenes & Development
Year2025
Peer reviewedYes
Record last updated2026-08-22
SourceDOI 10.1101/gad.352084.124 · PMID 39572234 · Free full text (PMC11789495)

Extracted findings

InterventionN/A (review)
TargetmTORC1 pathway (nutrient/growth factor integration)
ModelN/A
EffectComprehensive review of mTORC1 regulation, metabolic control, and clinical outlook

In the Atlas

Related topics

mTORC1

Cite this paper

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He, L., Cho, S., & Blenis, J. (2025). mTORC1, the maestro of cell metabolism and growth. Genes & Development. https://doi.org/10.1101/gad.352084.124

@article{HE2025,
  author       = {He, L. and Cho, S. and Blenis, J.},
  title        = {{mTORC1, the maestro of cell metabolism and growth}},
  journal      = {Genes & Development},
  year         = {2025},
  doi          = {10.1101/gad.352084.124},
  note         = {PMID: 39572234},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper. 

Barton, O. (2026). Oliver's mTOR Atlas (record HE2025) [Data set]. https://mtor-atlas.org/study/HE2025/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HE2025,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HE2025},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HE2025/},
  doi          = {10.5281/zenodo.22059963}
}