Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E

We genetically dissect the contribution of the most prominent downstream translational components of mTOR signaling toward Akt-driven lymphomagenesis. While phosphorylation of rpS6 is dispensable for cancer formation, 4EBP-eIF4E exerts significant control over cap-dependent translation, cell growth, cancer initiation, and progression. This effect is mediated at least in part through 4EBP-dependent control of Mcl-1 expression, a key antiapoptotic protein. By using an active site inhibitor of mTOR, PP242, we show a marked therapeutic response in rapamycin-resistant tumors.

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Hsieh, A. C., et al. (2010). Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer cell. https://doi.org/10.1016/j.ccr.2010.01.021

@article{HSI2010,
  author       = {Hsieh, A. C. and Ruggero, D. and others},
  title        = {{Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E}},
  journal      = {Cancer cell},
  year         = {2010},
  doi          = {10.1016/j.ccr.2010.01.021},
  note         = {PMID: 20227039},
}

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The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record HSI2010) [Data set]. https://mtor-atlas.org/study/HSI2010/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_HSI2010,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record HSI2010},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/HSI2010/},
  doi          = {10.5281/zenodo.22059963}
}