Carvedilol attenuates PTZ-induced epileptogenesis: associations with hippocampal neuroinflammation and PI3K/AKT/mTOR-related alterations.

Epileptogenesis is a multifactorial process driven by persistent neuroinflammation, oxidative stress and dysregulated intracellular signalling. This study investigated prophylactic carvedilol in the PTZ-induced kindling model. Repeated PTZ administration produced progressive behavioural seizure development, impaired open-field performance, hippocampal neuronal damage, reduced GABA, increased oxidative stress and inflammatory mediators, altered hippocampal NLRP3 expression and changes in PI3K-, AKT- and mTOR-related protein expression.

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Madkour, A. H., Abdelaziz, R. R., Nader, M. A., & Elshal, M. (2026). Carvedilol attenuates PTZ-induced epileptogenesis: associations with hippocampal neuroinflammation and PI3K/AKT/mTOR-related alterations. Scientific Reports. https://doi.org/10.1038/s41598-026-67306-2

@article{MADKOUR2026,
  author       = {Madkour, A. H. and Abdelaziz, R. R. and Nader, M. A. and Elshal, M.},
  title        = {{Carvedilol attenuates PTZ-induced epileptogenesis: associations with hippocampal neuroinflammation and PI3K/AKT/mTOR-related alterations}},
  journal      = {Scientific Reports},
  year         = {2026},
  doi          = {10.1038/s41598-026-67306-2},
  note         = {PMID: 42642481},
}

Cite this Atlas record

The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record MADKOUR2026) [Data set]. https://mtor-atlas.org/study/MADKOUR2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_MADKOUR2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record MADKOUR2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/MADKOUR2026/},
  doi          = {10.5281/zenodo.22059963}
}