Translational repression of 5' TOP mRNAs in chronically activated CD8+ T cells.

T cell exhaustion is a dysfunctional state that arises during chronic infections and cancer, characterized by impaired effector functions and sustained expression of inhibitory receptors. We performed ribosome profiling and RNA sequencing on chronically activated human CD8+ T cells to globally assess translational control during a model of T cell exhaustion. Our analyses reveal a marked repression of 5' terminal oligopyrimidine (TOP) mRNAs during chronic activation. Unexpectedly, we demonstrate that this translational repression occurs despite evidence of elevated mTOR activity.

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Pledger, E. S., Ambavaram, N., Ferguson, L., & Cate, J. H. D. (2026). Translational repression of 5' TOP mRNAs in chronically activated CD8+ T cells. RNA biology. https://doi.org/10.1080/15476286.2026.2715355

@article{PLEDGER2026,
  author       = {Pledger, E. S. and Ambavaram, N. and Ferguson, L. and Cate, J. H. D.},
  title        = {{Translational repression of 5' TOP mRNAs in chronically activated CD8+ T cells}},
  journal      = {RNA biology},
  year         = {2026},
  doi          = {10.1080/15476286.2026.2715355},
  note         = {PMID: 42558000},
}

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The record is the Atlas's own work — the evidence label, the extracted findings and the links. It is cited as part of the dataset, not as the paper.

Barton, O. (2026). Oliver's mTOR Atlas (record PLEDGER2026) [Data set]. https://mtor-atlas.org/study/PLEDGER2026/ · Dataset DOI 10.5281/zenodo.22059963

@misc{atlas_PLEDGER2026,
  author       = {Barton, Oliver},
  title        = {{Oliver's mTOR Atlas}, record PLEDGER2026},
  howpublished = {Data set},
  year         = {2026},
  url          = {https://mtor-atlas.org/study/PLEDGER2026/},
  doi          = {10.5281/zenodo.22059963}
}